mardi 25 juillet 2017
Catégorie : ACTUALITES, Ingrédients, Innovation, Preuves cliniques | Auteur : experts

NOL, Nutraveris Online, la Data solution la plus efficace pour créer et lancer vos nouveaux produits au sein des 28 Etats membres de l’Union Européenne, utilisée depuis plus de 10 ans par plus de 500 industriels,  vous informe : 


The objective of this randomized, double-blind, placebo-controlled intervention study, was to evaluate the safety and tolerance of 3 probiotic strains (Bifidobacterium longum subsp. infantis R0033, Bifidobacterium bifidum R0071 and Lactobacillus helveticus R0052) in 221 healthy infants aged 3 to 12 months. They received either a placebo or one of the 3 probiotic strains (3×109cfu) daily during 8 weeks.

The results showed that changes in growth (weight, height and head circumference) were equivalent in all 4 groups. No SAEs were reported. Total number of AEs recorded was equivalent in all groups. Thus, the use of B. infantis, L. helveticus and B. bifidum in infancy is safe, and well tolerated.


safety and tolerance of 3 probiotic strains

Flow chart of the study


Manzano S, De Andrés J, Castro I, Rodríguez JM, Jiménez E, Espinosa-Martos I. Safety and tolerance of three probiotic strains in healthy infants: a multi-centre randomized, double-blind, placebo-controlled trial. Benef Microbes. 2017 May 30:1-10.


This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…


More information on

Contact our Scientific & Regulatory experts at NUTRAVERIS, +33 2 96 76 54 87


Laisser un commentaire