Nutraveris
Thursday, October 18, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this randomized, double-blinded and placebo-controlled study was to examine the anti-inflammatory and analgesic effects of a garlic supplement in overweight or obese women with knee osteoarthritis (OA). 80 women with mild to moderate knee OA have been enrolled. They received either a placebo or 1000 mg of garlic tablets for 12 weeks.

 

Garlic

 

Despite an unchanged TNF-α level within or between the two groups, the pain scores were significantly reduced in the garlic group (p = 0.002 vs. baseline), but not in the placebo group (p = 0.674 vs. baseline). The comparison between the two groups revealed a significant difference after 12 weeks (p = 0.043). Resistin concentrations have been reduced in the garlic group (p = 0.008).

 

Based on these results, garlic may be effective for the management of OA-related joint pain, which may, at least in part, be mediated via a reduction in resistin, a pro-inflammatory cytokine.

 

 

Dehghani S, Alipoor E, Salimzadeh A, Yaseri M, Hosseini M, Feinle-Bisset C, Hosseinzadeh-Attar MJ. The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis. Phytomedicine. 2018 Sep 15;48:70-75.

 

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Tuesday, October 16, 2018
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This meta-analysis of 7 randomized and controlled trials focusses on the potential interest of omega 3 fatty acids supplementation in women with gestational diabetes. Results showed large benefits of such supplementations for the reduction of fasting plasma glucose (SMD = -0.56, 95% CI: -0.83 to -0.24, p = 0.0005) and insulin sensitivity assessed by HOMA-IR (SMD = -0.52, 95% CI: -0.83 to -0.21, p = 0.001).

 

Omega 3 polyunsaturated fatty acids and gestational diabetes

 

However, omega 3 fatty acid supplementation had no significant effects on macrosomia (high fetal body weight, p = 0.06), newborn’s hyperbilirubinemia (p = 0.08), preterm delivery (p = 0.16) and preeclampsia (p = 0.59). However, supplementation reduced high sensitivity C-reactive protein (SMD = -1.14, 95% CI: -2.0 to -0.29, p = 0.009).

 

The authors concluded that omega 3 fatty acids supplementation can provide substantially beneficial effects on glycemic control and inflammatory response for gestational diabetes.

 

Gao L, Lin L, Shan N, Ren CY, Long X, Sun YH, Wang. The impact of omega-3 fatty acid supplementation on glycemic control in patients with gestational diabetes: a systematic review and meta-analysis of randomized controlled studies. J Matern Fetal Neonatal Med. 2018 Sep 19:1-191.

 

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Thursday, October 11, 2018
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The aim of this randomized, single-blind study was to test whether a supplementation with a tomato paste purèe could improve some haemodynamic parameters in healthy volunteers before and after a standardized fat meal (FM), for 7 days.

Tomato paste

Nineteen healthy male volunteers were randomized either to a low fiber diets (LFD) and tomato paste arm (80 g of tomato paste /day) for 7-days, or to a control arm (LFD-only) with a 2-week washout period.

The difference in Stiffness Index was increased in the LFD and tomato paste + FM-arm, as compared to the LFD-only + FM arm at both 2 and 3.5 h points. After the FM, in both arms, at 2 h, a reduction in the Reflection Index and an increase in heart rate were observed. Interestingly, only in the LFD and tomato paste + FM-arm, some haemodynamic changes were detectable at 2 h; notably, there was an increase in brachial artery diameter and a reduction in diastolic blood pressure.

 

Tomato paste acutely modifies some haemodynamic parameters triggered by fat meal, suggesting possible haemodynamic beneficial effects in people consuming tomatoes.

 

Dalbeni A, Treggiari D, Tagetti A, Bevilaqua M, Bonafini S, Montagnana M, Scaturro G, Minuz P, Fava C. Positive Effects of Tomato Paste on Vascular Function After a Fat Meal in Male Healthy Subjects. Nutrients. 2018 Sep 15;10(9).

 

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Monday, October 8, 2018
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The authors of this study examined the neuroprotective effects of walnut peptides (Juglans regia). They used a rat model of memory impairment due to sleep deprivation. The walnut protein hydrolysate had significant effects on behavioral performance in the Marris water maze test, a task used to study spatial learning and memory. These effects were associated with an improvement in antioxidant defenses with the walnut preparation.

 

Walnut

 

In addition, the authors showed that three neuroprotective peptides (GGW, VYY and LLPF) had significant neuroprotective properties in PC12 cells treated with glutamate. Once again, these peptides had strong radical scavenging properties.

 

In conclusion, walnut peptides may be used for the management of neurodegenerative disorders characterized by memory deficits. However, these pre-clinical results should be confirmed in humans.

 

 

Wang S, Su G, Zhang Q, Zhao T, Liu Y, Zheng L, Zhao M. Walnut (Juglans regia) peptides reverse sleep deprivation-induced memory impairment in rat via alleviating oxidative stress. J Agric Food Chem. 2018 Sep 18.

 

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Friday, October 5, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

To determine the effects of cumin supplementation (Cuminum cyminum L.) on plasma lipids, the authors of this systematic review and meta-analysis have compiled results from 6 randomized and controlled studies (376 subjects).

 

cumin

 

They showed that cumin supplementation can reduce plasma concentration of total cholesterol (mean difference (MD) = -10.90 mg/dL, 95% CI: -21.39, -0.42, p = 0.042) and LDL-cholesterol (MD = -6.94 mg/dL, 95% CI: -11.53, -2.35, p = 0.003) in comparison to control treatment.

In addition, HDL-cholesterol levels were found to be increased by the supplementations (MD = 3.35 mg/dL, 95% CI: 1.58, 5.12, p < 0.001). Finally, cumin tended to decreased triglycerides levels (MD = -20.48 mg/dL, 95% CI: -41.23, -0.26, p = 0.053).

 

In conclusion, this meta-analysis suggest that cumin supplementation is effective for the management of dyslipidemia.

 

Hadi A, Mohammadi H, Hadi Z, Roshanravan N, Kafeshani M. Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2018 Aug 8.

 

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