Nutraveris
Wednesday, April 25, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10 years by more than 500 industry leaders informs you:

 

This randomized and double-blinded study aimed to examine the acute hematological and mood perception response to p-synephrine, alone or with caffeine, during quite sitting. 16 subjects have been enrolled and received 6 supplementations in a random order: 1) 103 mg p-synephrine, 2) 233 mg caffeine + 104 mg p-synephrine, 3) 240 mg caffeine, 5) 337 mg caffeine + 46 mg p-synephrine, 5) 325 mg caffeine, and 6) placebo.

Participants sat for 3 hours, and were asked to complete mood questionnaire every 30 min. Moreover, blood sample have been withdrawn before and 3h after the supplementation to assess immune, lipid and chemistry parameters.

p-synephrine

Results showed that caffeine increased feelings of attention, excitement, energy and vigor.

Compared with placebo, p-synephrine did not exhibit significant effects, except of differential time effects on hematocrit (decrease in placebo and no change with p-synephrine), triglycerides and VLDL lipoproteins (no change with placebo and decrease with p-synephrine) and iron (no change with placebo, increase with p-synephrine).

 

The authors concluded that 103 mg p-synephrine has no negative impact on acute blood parameters, does not interact with caffeine or affect mood.

 

Bush JA, Ratamess NA, Stohs SJ, Ellis NL, Vought IT, O’Grady EA, Kuper JD, Kang J, Faigenbaum AD. Acute hematological and mood perception effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine: A placebo-controlled, double-blind study. Phytother Res. 2018 Apr 19.

 

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Thursday, April 19, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

Topical applications of Centella asiatica are traditionally used for the management of skin disorders and wound healing. However, the effects of oral C. asiatica for wound healing remained unclear. The purpose of this study was to examine the efficacy of a new C. asiatica extract, Centellium® (Horphag Research Ltd.) on wound healing.

Centella asiatica

129 patients receiving abdominal or knee surgery have been enrolled. They received short-term antibiotic prophylaxis, with or without 550 mg/day of the extract (from the 2nd to the 6th week after surgery). Results showed that the treatment was well-tolerated and no side effect was reported. The ultrasound-assessed scar tissue regularity was on average lower in controls than in supplemented subjects (p < 0.05). Scars also appeared to be significantly more homogeneous in supplemented patients than in controls.

 

This study suggest for the first time that an oral supplementation in C. asiatica extract may facilitate the regular healing of surgical scars.

 

 

Cotellese R, Hu S, Belcaro G, Ledda A, Feragalli B, Dugall M, Hosoi M, Ippolito E. Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids. Minerva Chir. 2018 Apr;73(2):151-156.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
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With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

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Tuesday, April 17, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

Aged garlic is known to have various benefits in humans. This study examined whether aged garlic can reduce chronic inflammation and improve immune function in adults with obesity.

Aged garlic

51 healthy adults with obesity have been enrolled in this randomized, double-blind and placebo-controlled trial.

They received a placebo or 3.6 g of aged garlic extract for 6 weeks.

The garlic supplementation has reduced serum IL-6 (p = 0.04) and TNF-α (p = 0.05) levels in comparison to placebo. In addition, results showed a higher proportion of γδ-T cells (p = 0.03) and a lower proportion of NKT cells (p = 0.02) in the total population of lymphocytes. Finally, a significant difference in blood LDL-cholesterol concentration has been measured.

 

Consequently, this study showed that aged garlic extract for 6 weeks may reduce chronic inflammation associated with obesity, and module immune cell distribution.

  

Xu C, Mathews AE, Rodrigues C, Eudy BJ, Rowe CA, O’Donoughue A, Percival SS. Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr ESPEN. 2018 Apr;24:148-155.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
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With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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contact@nutraveris.com, +33 2 96 76 54 87

Friday, April 13, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This study conducted in mice has examined whether a supplementation with Lactobacillus plantarum MTCC 9510 may protect against the consequences of unpredictable stress and sleep deprivation. Animals received 2 x 1010 CFU of probiotic, and were either subjected to chronic unpredictable mild stress and sleep deprivation stress.

Lactobacillus plantarum MTCC9510

Results showed that L. plantarum MTCC 9510 prevented stress-induced behavioral despair, such as depression, anxiety, learning and memory, and stereotypic behavior. Moreover, it also improved oxidative stress markers, inflammatory cytokines in brain and serum and gut and blood brain barrier integrity. Finally, intestinal microbiota has been positively affected by the supplementation.

 

Therefore, these preclinical results suggest that L. plantarum MTCC 9510 may help to manage stress-induced disturbances, notably in case of sleep deprivation.

 

 Dhaliwal J, Singh DP, Singh S, Kumar PA, Boparai RK, Bishnoi M, Kondepudi KK, Chopra K. Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation induced behaviour, biochemical and selected gut microbial aberrations in mice. J Appl Microbiol. 2018 Mar 25.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Wednesday, April 11, 2018
Category : Formation | Author : experts | Comment : No Comments
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