Nutraveris
Thursday, December 6, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

Kava Kava (Piper methysticum) has been shown to be effective for the management of anxiety.

The aim of this meta-analysis was to confirm these beneficial effects. 11 articles have been included in the analysis. In comparison to placebo, Kava Kava was more effective in 3 of 7 trials. A risk ratio of 1.50 (95% CI: 1.12-2.01) from responder rate was calculated in favor of the intervention from 5 clinical trials.

Kava Kava

Kava Kava, which is known to possibly induce liver damage, did not induce more side effects than placebo (p = 0.574). Only two studies among the 11 included in the analysis reported increase liver markers following supplementation.

 

The authors concluded that Kava Kava is a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use. However, results of clinical studies are not so clear, and the risk of hepatotoxicity limits the use of Kava Kava in humans.

 

 

Smith K, Leiras C. The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials. Complement Ther Clin Pract. 2018 Nov;33:107-117.

 

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Tuesday, December 4, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This systematic review and meta-analysis of randomized controlled trials was conducted to clarify the effect of melatonin supplementation on glycemic control.

Twelve trials were identified eligible to be included in current meta-analysis. The pooled findings indicated that melatonin supplementation significantly reduced fasting glucose (SMD = -6.34; 95% CI, -12.28, -0.40; p = 0.04; I2: 65.0) and increased the quantitative insulin sensitivity check index (SMD = 0.01; 95% CI, 0.00, 0.02; p=0.01; I2: 0.0).

 

Melatonin chemical structure

 

However, melatonin administration did not significantly influence insulin levels (SMD = -1.03; 95% CI, -3.82, 1.77; p = 0.47; I2: 0.53), homeostasis model assessment of insulin resistance (HOMA-IR) (p = 0.37) or HbA1c levels (p = 0.08).

The current meta-analysis showed a promising effect of melatonin supplementation on glycemic control through reducing fasting glucose and increasing the quantitative insulin sensitivity check index.

 

Doosti-Irani A, Ostadmohammadi V, Mirhosseini N, Mansournia M, Reiter RJ, Kashanian M, Rahimi M, Razavi M, Asemi Z. The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2018 Nov;50(11):783-790.

 

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Thursday, November 29, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This study aim was to determine whether consumption of the soy isoflavones, genistein and daidzein, differentially influence metabolic syndrome. C57BL/6J mice were fed with low fat diet (LF), western-style diet (WD), and WD containing 0.16% (w/w) of genistein (WD + G) or daidzein (WD + D) for 10 weeks.

 

Genistein and daidzein

 

Intake of WD + G and WD + D produced a robust decrease in body weight gain by 40% and 19%, respectively (p < 0.05). Genistein reduced energy intake by 26%, and daidzein decreased energy intake by 8% (p < 0.05). A glucose tolerance test indicated that genistein consumption significantly decreased the incremental areas under the curve (AUC) from 60-120 min, compared to WD-fed mice.

Authors concluded addition of genistein, compared to daidzein, to a western-style diet, more profoundly decreased food intake and body weight gain.

 

Luo T, Miranda-Garcia O, Sasaki G, Wang J, Shay NF. Genistein and daidzein decrease food intake and body weight gain in mice, and alter LXR signaling in vivo and in vitro. Food Funct. 2018 Nov 7.

 

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Tuesday, November 27, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this study is to review available data about renal safety of the most prominent amino acid supplements including L-arginine, glutamine and also L-carnitine as well as creatine (as AA derivatives) in athletes and bodybuilders.

Arginine appears to have both beneficial and detrimental effects on kidney function. However, adverse effects are unlikely to occur with the routine doses (from 3 to >100 g/day).

L-carnitine up to 6000 mg/day is generally considered to be a safe supplement at least in healthy adults.

Both short-term (20-30 g within a few hours) and long-term (0.1 g/kg 4 times daily for 2 weeks) glutamine supplementation in healthy athletes were associated with no significant adverse effects, but it can cause glomerulosclerosis and serum creatinine level elevation in the setting of diabetic nephropathy.

Creatine supplementation (ranged from 5 to 30 g/day) also appears to have no detrimental effects on kidney function of individuals without underlying renal diseases.

The pathways of L-arginine biosynthesis and metabolism in humans.

The pathways of L-arginine biosynthesis and metabolism in humans. L-arginine can be metabolized to various compounds through enzymatic pathways. These metabolites can affect many organs of the body including kidney.

Davani-Davari D, Karimzadeh I, Sagheb MM, Khalili H. The Renal Safety of L-Carnitine, L-Arginine, and Glutamine in Athletes and Bodybuilders. J Ren Nutr. 2018 Oct 16.

 

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Thursday, November 22, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this experiment was to examine the effects of pineapple juice on high-fat diet-induced obesity in rats. Animals were divided in a control group and a high-fat diet group, and received their allocated diet for 7 weeks. Then, obese animals were divided in three groups: high-fat diet + water, normal diet + pineapple juice, or high-fat diet + pineapple juice. The raw pineapple juice was added to water (15% V/V) and bottles were changed every day.

 

Pineapple juice

 

In comparison to the obese control group, pineapple has reduced body weight and BMI. The pineapple juice also improved liver fat deposition, serum glucose, insulin and plasma lipids levels. The administration of juice downregulated the increment of Fatty Acid Synthase (FAS) and Sterol Regulatory element-Binding Protein-1c (SREBP-1c) mRNA expression in liver, and upregulated Hormone Sensitive Lipase (HSL) and glucose transporter 2 (GLUT-2) expressions.

 

Therefore, this pre-clinical results confer to pineapple a potential anti-obesity effect, which may be explained by a decreased lipogenesis and an increased lipolysis.

 

 

El-Shazly SA, Ahmed MM, Al-Harbi MS, Alkafafy ME, El-Sawy HB, Amer SAM. Physiological and molecular study on the anti-obesity effects of pineapple (Ananas comosus) juice in male Wistar rat. Food Sci Biotechnol. 2018 Apr 11;27(5):1429-1438.

 

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  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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