Thursday, July 5, 2012
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts
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Neural tube defects can be prevented with periconceptional intake of folic acid in about 70% of cases. But a proportion of neural tube defects cases might be resistant to folic acid. Inositol isomers can prevent folate-resistant neural tube defects in the curly-tail mutant mouse, suggesting that some cases of human neural tube defects might benefit from inositol supplementation. Twelve Caucasian women from different parts of Italy with at least one previous neural tube defects-affected pregnancy underwent periconceptional combined myo-inositol and folic acid supplementation. All babies were born without any type of neural tube defects. Therefore, inositol associated with folic acid would permit to prevent neural tube defects.

Références: Cavalli P, Tonni G, Grosso E, Poggiani C. Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. Birth Defects Res A Clin Mol Teratol. 2011 Nov;91(11):962-5.

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