Tuesday, July 17, 2012
Category : Non classé | Author : experts
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An experiment highlighting the involvement of gut microbiota in the effects of a high-fat diet in mice has been presented at the European Congress of obesity which has been held in Lyon from May 9th to May 12th. Since the mice response to high-fat diet may be heterogeneous, the authors have isolated gut microbiota from responding mice (i.e. developing obesity, inflammation and type 2 diabetes) and from non–responding mice. These samples have been then transferred into germ-free mice. These animals have been fed with the high-fat diet, and the authors have observed that mice with microbiota of responding animals have developed an insulin resistance and disturbances in hepatic lipid metabolism. Conversely, the mice with microbiota of non-responding animals have not developed any diseases for a similar weight gain. This study shows therefore that insulin resistance and hepatic steatosis are transmissible by microbiota transfer that shows its causal role.

Reference: Le Roy T. et al. (2012) « Gut microbiota transplantation demonstrates its causal role in the development of type 2 diabetes and fatty liver » Obes Facts, 5 (suppl 1):41

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