Nutraveris
Thursday, June 13, 2013
Category : Non classé | Author : experts
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The aim of the study was to evaluate the effect of alpha-lipoic acid(ALA) on temporary threshold shift measured 2 minutes after the end of exposure (TTS(2)) induced by a 3 kHz tone in young normally hearing subjects.

30 young normal hearing volunteers served as control subjects. Individuals were randomly assigned to three groups. Group A (10 subjects) subjects were exposed to a 90 dB HL 3 kHz pure tone for 10 min. Group B (10 subjects) subjects were exposed to a 90 dB HL 3 kHz pure tone one hour after oral ingestion of 600 mg of ALA. Group C (10 subjects) were exposed to a 90 dB HL 3 kHz pure tone after 10 days of oral ingestion of 600 mg of ALA.
Statistical analysis showed that prior to the exposure the hearing thresholds did not differ significantly among the three groups. TTS(2) of group C was significantly lower that TTS2 of Groups A and B at 6 kHz (p=0.03), and TEOAEs amplitude change after noise exposure was lower for group C compared to Groups A (p=0.089) and B (p=0.03). A single dose of 600 mg of dose ALA did not induce any protection on the TTS(2) induced by a 90 dB HL 3 kHz tone, while 10 days of therapeutic dosage assumption of ALA was associated with significant protection at 6 kHz.
The results of this study show that a short course of ALA protects from TTS(2) in humans, and therefore further studies are needed to better define the role of ALA in the prevention of noise induced hearing loss.

Acta Otorhinolaryngol Ital. 2012 Dec;32(6):380-385
The effect of alpha-lipoic acid on temporary threshold shift in humans: a preliminary study.
Quaranta N, Dicorato A, Matera V, D’Elia A, Quaranta A

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