Nutraveris
Thursday, September 29, 2016
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

 

Methylsulfonylmethane (MSM), an organosulfur compound, is used as a dietary supplement for the improvement of mobility in human.

In this study, the effect of MSM on obesity-linked metabolic disorders have been investigated. The goal of the current study was to determine whether MSM has beneficial effects on glucose and lipid homeostasis in obesity-associated pathophysiologic states. High-fat diet-induced obese and genetically obese diabetic db/db mice treated with MSM (1%-5% v/v, by drinking water) were studied. Metabolic parameters involved in glucose and lipid metabolism were determined. Treatment of diet-induced obese mice with MSM leads to a significant decrease in blood glucose levels (cf figure). Diet-induced obese mice treated with MSM are hypersensitive to insulin, as evidenced by decreased serum insulin and an increase in the area above the curve. In db/db mice, a marked impairment in glucose and lipid metabolic profiles is notably ameliorated when MSM is supplemented. These data suggest that MSM has beneficial effects on multiple metabolic dysfunctions, including hyperglycemia, hyperinsulinemia, insulin resistance, and inflammation. Thus, MSM could be the therapeutic option for the treatment of obesity-related metabolic disorders in human such as type 2 diabetes and fatty liver diseases.

 

graphe-msm

Figure: MSM treatment reduces blood glucose levels and ameliorates insulin sensitivity in db/db mice.

Sousa-Lima I, Park SY, Chung M, Jung HJ, Kang MC, Gaspar JM, Seo JA, Macedo MP, Park KS, Mantzoros C, Lee SH, Kim YB. Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Metabolism. 2016 Oct;65(10):1508-21.

 

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