Tuesday, October 25, 2016
Category : NEWS, CONVICTIONS, INGREDIENTS, INNOVATION, food safety | Author : experts | Comment : No Comments



As the leading European consultancy in nutrition and health, Nutraveris has worked with the Korean company Naturalendo Tech Co., Ltd in order to obtain the authorization to put EstroG-100® on the European market. Estro-G100® is a hot-water extract of a mixture of three herbal roots (Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz and Angelica gigas Nakai), already used in Korea, USA and Canada for the management of menopausal symptoms. After an initial evaluation from Ireland that didn’t raise any safety concern, EFSA was mandated by the European Commission at the request of some Member States for a scientific evaluation.

EFSA has now recognized that EstroG-100® is safe for the use of food supplements intended for post-menopausal women. The application provided a full characterization of the three botanicals as of the combination. Moreover, the safety of EstroG-100 was substantiated by in vitro and in vivo studies conducted either with EstroG-100® or single herbs. The applicant provided also two human clinical trials highlighting the safe use of EstroG-100® in post-menopausal women.

This success demonstrates once again the strengths of Nutraveris, either in the preparation and submission of Novel Food applications, and in its follow-up during Member States and EFSA evaluations.

Do not hesitate to contact our team to obtain authorization for your ingredients.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

In this randomized, double-blind, placebo-controlled clinical trial was investigated the effect of quercetin supplementation (500 mg/day) or placebo group for 8 weeks on inflammation, disease severity, and clinical symptoms in 50 women with rheumatoid arthritis (RA).


Results show quercetin supplementation for 8 weeks significantly reduced early morning stiffness, morning pain, and after-activity pain (p < 0.05).

Disease Activity Score 28 and assessment questionnaire scores decreased in the quercetin group compared to placebo and the number of patients with active disease significantly decreased in the quercetin group.

Plasma hs-TNFα level was significantly reduced in the quercetin group compared to placebo (p < 0.05).

There were no significant differences in tender and swollen joint counts between groups but tender joint counts significantly decreased in the quercetin group after the intervention. Supplementation had an effect on erythrocyte sedimentation rate but it was not significant (p > 0.05).

Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, Jazayeri S. The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. J Am Coll Nutr. 2016 Oct 6:1-7.

This information has been sourced by NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders.

This collaborative and complete tool contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

Formulate new innovative products

Check if your already existing formulas are still compliant with the in force regulations

Adapt your existing formulas to the requirements of other European countries where you are willing to export them

Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…


More information on

Contact our Scientific & Regulatory experts at NUTRAVERIS, +33 2 96 76 54 87