Nutraveris
Thursday, November 10, 2016
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

In this study, polysaccharide from the mycelia of Ganoderma lucidum was given via oral administration to rats (100 mg/kg body weight, 21 days) to investigate its effects on intestinal barrier functions.

It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-κB p65 (NF-κB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase in serum (DAO). Meanwhile, rats from the polysaccharide group showed significant higher microbiota richness in cecum compared with the control group. Moreover, the polysaccharide decreased the Firmicutes-to-Bacteroidetes ratio.

Ganoderma lucidum

Figure: Effects of G. lucidum treatment on the levels of IFN-γ (A), IL-2 (B), IL-4 (C), IL-6 (D) and DAO (E) in serum and SIgA (F) in ileum. CON (in red): control group; GLP (in green): G. lucidum polysaccharide group. Data are representative as means ± SEM (n = 4 of each group). * P < 0.05, compared with the control group.

In this study, G. lucidum significantly improved the level of IFN-γ, IL-2 and IL-4 in serum compared with the control group. IFN-γ, which is mainly secreted by natural killer (NK) cells and T cells as part of innate immunity and antigen-specific immunity, is a key cytokine against pathogen infections and tumors in innate and adaptive immunity.

The present study showed that G. lucidum could improve intestinal barrier integrity, regulate the intestinal immune functions and modulate the composition of intestinal microbiota. Then, the polysaccharide from the mycelia of Ganoderma lucidum might be used as functional agent to regulate the intestinal barrier functions.

 

Jin M, Zhu Y, Shao D, Zhao K, Xu C, Li Q, Yang H, Huang Q, Shi J. Effects of polysaccharide from mycelia of Ganoderma lucidum on intestinal barrier functions of rats. Int J Biol Macromol. 2016 Sep 29;94(Pt A):1-9.

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