Thursday, November 17, 2016

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

The aim of the study was to investigate the ameliorative potential of different extracts of Hemidesmus indicus to experimental high-fat diet in wistar rats, and their possible mechanism of action.

Male wistar rats were divided into 6 groups (n=6/group) and fed with a standard diet (control), high-fat diet (HFD), high-fat diet supplemented with different extracts and positive control for 9 weeks. Oral administration of methanolic extract of H. indicus (200 mg/kg) offered a significant dose-dependent protection against HFD-induced oxidative stress, as reflected in the levels of catalase (p<0.001 in the aorta, heart and liver), superoxide dismutase (p<0.001 in the aorta, heart and liver), and glutathione peroxidase (p<0.001 in the aorta, heart and liver).


Table: Effect of different extracts of Hemidesmus indicus on plasma lipid profile in control and experimental rats.

Values are expressed as mean ± SEM (n = 6). Data were analyzed using One-way analysis of variance followed by Dunnett’s multiple comparison test. ***p<0.001, *p<0.05; *p<0.05 considered significant; ns: non-significant; All groups are compared with normal control. BW: body weight; TC: total cholesterol; FC: free cholesterol; EC: ester cholesterol.


Hyperlipidemia condition assessed in terms of body weight, total cholesterol, free cholesterol, ester cholesterol, phospholipids, triglycerides, and atherogenic index and the results showed significant differences between HFD and non-HFD fed rats (p<0.001).


Venkateshan S, Subramaniyan V, Chinnasamy V, Chandiran S. Anti-oxidant and anti-hyperlipidemic activity of Hemidesmus indicus in rats fed with high-fat diet. Avicenna J Phytomed. 2016 Sep-Oct;6(5):516-525.


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