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Superiority of Chondroitin sulfate over Celecoxib at reducing cartilage volume loss in knee OA patients

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The aim of this study was to assess the structure-modifying effect of chondroitin sulfate (CS) in osteoarthritis (OA) using quantitative magnetic resonance imaging (qMRI).

This was a 24-month, randomised, double-blind, double-dummy, controlled, comparative exploratory study of knee OA in 138 patients.

The primary endpoint was to determine the effect of CS 1200 mg/day versus celecoxib 200 mg/day on cartilage volume loss (CVL) in the lateral compartment over time as measured by qMRI.

Secondary endpoints included assessment of the OA structural changes and signs and symptoms of OA.

Compared with celecoxib treatment, patients treated with CS had a significant reduced CVL at 24 months in the medial compartment (celecoxib -8.1 % ± 4.2, CS -6.3 % ± 3.2; p = 0.018) and medial condyle (-7.7 % ± 4.7, -5.5 % ± 3.9; p = 0.008); no significant effect was seen in the lateral compartment.

knee-oa-patient [2]

Both groups experienced a marked reduction in the incidence of patients with joint swelling/effusion and in symptoms over time.

Data showed similar good safety profiles including cardiovascular adverse events for both drugs.


Pelletier JP, Raynauld JP, Beaulieu AD, Bessette L, Morin F, de Brum-Fernandes AJ, Delorme P, Dorais M, Paiement P, Abram F, Martel-Pelletier J. Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study. Arthritis Res Ther. 2016 Nov 3;18(1):256.

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