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Tuesday, January 31, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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The aim of this study was to compare the effect of two seeds (flax and Salba-chia) on postprandial glycemia and satiety scores.

Fifteen healthy participants (age: 23.9±3 years; BMI: 22.2±0.8 kg/m2) were randomized to receive a 50 g glucose challenge, alone or supplemented with either 25 g ground Salba-chia or 31.5 g flax, on three separate occasions.

Both Salba-chia and flax reduced blood glucose area under the curve over 120 min by 82.5 ±19.7 mmol/l (p<0.001) and 60.0 ±19.7 mmol/l (p=0.014), respectively, relative to a glucose control (Figure).

Salba-chia reduced peak glucose (-0.64 ±0.24 mmol/l; p=0.030) and increased time to peak (11.3 ±3.8 min; p=0.015) compared with flax.

Salba-chia significantly reduced the mean ratings of desire to eat (p=0.005), and overall appetite score (p=0.012), when compared with flax.

Salba-chia seed improve postprandial glycemia and satiety in a better way than flaxseed

Mean incremental blood glucose response in 15 healthy individuals after administration of Salba-chia, flax or control test beverages for: (a) 120 min postprandial and (b) incremental area under the curve after 120 min. Different letters are significantly different (p<0.05).

Salba-chia appears to have the ability to convert glucose into a slow-release carbohydrate and affect satiety to a greater extent than flax, possibly due to the higher fiber viscosity.

In conclusion, Salba-chia may confer additional benefit than flax.

Vuksan V, Choleva L, Jovanovski E, Jenkins AL, Au-Yeung F, Dias AG, Ho HV, Zurbau A, Duvnjak L. Comparison of flax (Linum usitatissimum) and Salba-chia (Salvia hispanica L.) seeds on postprandial glycemia and satiety in healthy individuals: a randomized, controlled, crossover study. Eur J Clin Nutr. 2016 Dec 21.

 

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Thursday, January 26, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

In vitro studies have shown that ethyl acetate parts of aqueous extracts from Prunella vulgaris L. may inhibit acetylcholinesterase and may consequently possess some neurological effects.

 

Prunella vulgaris

 

The purpose of this study was to investigate the effects of Prunella vulgaris extract in scopolamine-induced memory impairment in rats.

Results have shown that the extract was able to attenuate scopolamine-induced brain senescence by improving behavioral performance and decreasing brain cell damage. Moreover, the authors confirmed the inhibition of the acetylcholinesterase activity by the Prunella vulgaris extract.

Taking together, these results suggest that Prunella vulgaris may be used as an anti-dementia dietary supplement, notably in subjects with neurodegenerative diseases.

 

Qu Z, Zhang J, Yang H, Gao J, Chen H, Liu C, Gao W. Prunella vulgaris L., an edible and medicinal plant, attenuates scopolamine induced memory impairment in rats. J Agric Food Chem. 2016 Dec 21.

 

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Tuesday, January 24, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

While Beta-hydroxy-beta-methylbutyrate (HMB) is commonly supplemented to maintain muscle in elderly and clinical populations, previous data also showed long-term HMB supplementation prevents age-related dendritic shrinkage and improves cognitive flexibility and working memory performance in rats.

 

Beta-hydroxy-beta-methylbutyrate (HMB)

 

This new study aim was to explore the cognitive effects by assessing visuospatial learning and memory with the Morris water maze.

Female rats were ovariectomized at 11 months of age to model human menopause. At 12 months of age, male and female rats received relatively short- or long-term (1- or 7-month) dietary HMB (450mg/kg/dose) supplementation twice a day prior to testing. Spatial reference learning and memory was assessed across four days in the water maze with four trials daily and a probe trial on the last day.

Consistent with previous work, there were age-related deficits in water maze performance in both sexes. However, these deficits were ameliorated in HMB-treated males during training and in both sexes during probe trial performance. Thus, HMB supplementation prevented the age-related decrement in water maze performance, especially in male rats.

 

Kougias DG, Hankosky ER, Gulley JM, Juraska JM. Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats. Physiol Behav. 2016 Dec 27;170:93-99.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, January 19, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

Grifola frondosa is a medical mushroom widely used in Asia for its immune-enhancing properties.

In this study, the effects of G. frondosa on depression have been examined in mice.

Grifola frondosa

Animals were fed with G. frondosa or Pleurotus ostreatus (control) for 1 or 5 days. The anti-depressant effect was assessed by the tail suspension test, the forced swim test and the open field test. The consumption of G. frondosa reduced the immobility time during the tail suspension test and the forced swim test both after 1 and 5 days. No significant hyperactivity has been observed in the open field test.

The authors examined also the involvement of the α-amino-3-hydroxy-5-methyl-4-4iso-xazole-propionic acid (AMPA) receptors in the anti-depressant effects of G. frondosa. The use of GYKI 52466, a specific AMPA blocker, inhibit the beneficial effects of G. frondosa. Therefore, G. frondosa has significant anti-depressant effects on mice through an action on AMPA.

These effects should now be investigated in humans with depressive symptoms.

 

 

 

Bao H, Ran P, Sun L, Hu W, Li H, Xiao C, Zhu K, Du J. Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice. Pharm Biol. 2017 Dec;55(1):299-305.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
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  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Monday, January 16, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This placebo-controlled study examined if supplementing trained cyclists with branched amino acids during training season affected select body composition, performance, and immune variables. Cyclists received either 12 g/day (6 g/d L-Leucine, 2 g/d L-Isoleucine and 4 g/d L-Valine) of either branched-chain amino acids (BCAAs, n = 9) or a maltodextrin placebo (PLA, n = 9) over a 10-week training season.

A significant interaction existed for body mass-normalized relative peak power (19% increase in the BCAA group pre- to post-study, p=0.01), and relative mean power (4% increase in the BCAA group pre- to post-study, p=0.01).

A significant interaction for neutrophil number existed (p=0.04), as there was a significant 18% increase within the PLA group from the pre- to post-study time point (p=0.01). Chronic BCAA supplementation improves sprint performance variables in endurance cyclists.

 

Effects of chronic BCAA supplementation on Wingate variables in cyclists

Effects of chronic BCAA supplementation on Wingate variables in cyclists

Pre-study (pre) and 10-week post-study (post) Wingate variables.

panel a: A group × time interaction was observed for peak power (p = 0.02), and the BCAA group increased peak power by 20 % compared to the pre-study time point (**p = 0.01) .

panel b: A group × time interaction was also observed for relative peak power (p = 0.01), and the BCAA group increased relative peak power by 19 % compared to the pre-study time point (**p = 0.01) .

panel c: A group × time interaction was observed for mean power (p = 0.01), and the BCAA group increased mean power by 4 % compared to the pre-study time point (**p = 0.01) .

panel d: No group × time interactions was observed for relative mean power (MP).

 

Given that BCAA supplementation blunted the neutrophil response to intense cycling training, BCAAs may benefit immune function during a prolonged cycling season.

Kephart WC, Wachs TD, Mac Thompson R, Brooks Mobley C, Fox CD, McDonald JR, Ferguson BS, Young KC, Nie B, Martin JS, Company JM, Pascoe DD, Arnold RD, Moon JR, Roberts MD. Ten weeks of branched-chain amino acid supplementation improves select performance and immunological variables in trained cyclists. Amino Acids. 2016 Mar;48(3):779-89.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87