Thursday, January 19, 2017
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments

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Grifola frondosa is a medical mushroom widely used in Asia for its immune-enhancing properties.

In this study, the effects of G. frondosa on depression have been examined in mice.

Grifola frondosa

Animals were fed with G. frondosa or Pleurotus ostreatus (control) for 1 or 5 days. The anti-depressant effect was assessed by the tail suspension test, the forced swim test and the open field test. The consumption of G. frondosa reduced the immobility time during the tail suspension test and the forced swim test both after 1 and 5 days. No significant hyperactivity has been observed in the open field test.

The authors examined also the involvement of the α-amino-3-hydroxy-5-methyl-4-4iso-xazole-propionic acid (AMPA) receptors in the anti-depressant effects of G. frondosa. The use of GYKI 52466, a specific AMPA blocker, inhibit the beneficial effects of G. frondosa. Therefore, G. frondosa has significant anti-depressant effects on mice through an action on AMPA.

These effects should now be investigated in humans with depressive symptoms.




Bao H, Ran P, Sun L, Hu W, Li H, Xiao C, Zhu K, Du J. Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice. Pharm Biol. 2017 Dec;55(1):299-305.


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