Nutraveris
Thursday, February 9, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

A meta-analysis was performed in order to determine the benefits/risks of St John’s wort use for depression.

 

St John's wort

 

27 clinical trials with a total of 3808 patients were reviewed, comparing the use of St John’s wort and SSRI.

In patients with depression, St John’s wort demonstrated comparable response (p<0.001) and remission (p<0.001) rate, and significantly lower discontinuation/dropout (p<0.001) rate compared to standard SSRIs. The pooled SMD from baseline HAM-D scores (p<0.001) also support its significant clinical efficacy in ameliorating depressive symptoms.

 

St John's wort Prisma

PRISMA flowchart showing the studies identified during the literature search and abstraction process.

 

Evidence on the long-term efficacy and safety of St. John’s wort is limited as the duration of all available studies ranged from 4 to 12 weeks.

It is also unclear if St John’s wort would be beneficial for patients with severe depression, high suicidality or suicide risk.

For patients with mild-to-moderate depression, St John’s wort has comparable efficacy and safety when compared to SSRIs.

 

        

 

Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis. J Affect Disord. 2017 Jan 3;210:211-221.

 

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