Nutraveris
Thursday, March 2, 2017
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, multicenter, open-label, parallel group, active-controlled study aimed at comparing efficacy and safety of APT198K (xyloglucan plus heat-killed Lactobacillus reuteri SGL01 and Bifidobacterium brevis SGB01) versus a lactase dietary supplement as first-line treatment of infantile colic.

46 infants aged 3-16 weeks with infantile colic, received APT198K (xyloglucan 0.6 g/ml plus heatkilled L. reuteri SGL01 100 × 10(9) CFU/g and B. brevis SGB01 100 × 10(9) CFU/g) or a dietary supplement containing lactase 0.40 g (minimum 45,000 ONPGU/g) for 10 days.

xyloglucan plus L. reuteri and B. brevis for infantile colic

Mean duration of crying per episode: days with a significant difference between treatments

 

Number and duration of crying episodes decreased significantly versus baseline in both groups. On day 8, the mean duration of crying per episode was significantly shorter in the APT198K group compared with the lactase group (9.14 ± 5.34 vs 13.22 ± 5.29 min; p = 0.014) and remained so up to day 11.

 

Authors concluded APT198K decreased the mean duration per crying episode significantly more than a lactase dietary supplement in infants with colic.

 

Vandenplas Y, Bacarea A, Marusteri M, Bacarea V, Constantin M, Manolache M. Efficacy and safety of APT198K for the treatment of infantile colic: a pilot study. J Comp Eff Res. 2017 Jan 24.

 

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