Thursday, March 23, 2017

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The aim of this randomized, double-blind, placebo-controlled study was to examine the effects of prebiotic supplementation on appetite control and energy intake in 42 children with overweight and obesity.


Children were assigned to 8 g oligofructose-enriched inulin/d or placebo (maltodextrin), for 16 weeks. Compared with placebo, prebiotic intake resulted in significantly higher feelings of fullness (p = 0.04). Compared with placebo, prebiotic supplementation significantly reduced energy intake at the week 16 breakfast buffet in 11- and 12-years-olds (p = 0.04) but not in 7- to 10-y-olds. Fasting adiponectin (p = 0.04) and ghrelin (p = 0.03) increased at 16 weeks with the prebiotic compared with placebo. In ITT analysis, there was a trend for prebiotic supplementation to reduce BMI z score to a greater extent than placebo (-3.4%; p = 0.09).


Prebiotic supplementation in children with overweight and obesity improves appetite regulation.

Figure: Change (from baseline to 16 weeks) in fullness ratings taken before and after a breakfast buffet in participants receiving a prebiotic (n = 21) or placebo (n = 19). Values are means ± SEMs. *Different from placebo, p<0.05



Independent of other lifestyle changes, prebiotic supplementation in children with overweight and obesity improved subjective appetite ratings. This simple dietary change has the potential to help with appetite regulation in children with obesity.


Hume MP, Nicolucci AC, Reimer RA. Prebiotic supplementation improves appetite control in children with overweight and obesity: a randomized controlled trial. Am J Clin Nutr. 2017 Feb 22.


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