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The objective of this randomized, double-blind, placebo-controlled trial was to assess the effectiveness of Lactobacillus casei rhamnosus Lcr35 in the management of functional constipation in children. A total of 94 children aged <5 years with functional constipation according to the Rome III criteria, were assigned to receive L. rhamnosus (8×108 CFU, n = 46) or placebo (n = 48), twice daily, for 4 weeks.
There was no significant difference in treatment success between the placebo and the L. rhamnosus group (p = 0.4). There was a significant increase in the frequency of defecation from baseline to week 4 in both the placebo group (p < 0.001) and in the L. rhamnosus group (p < 0.001), but the defecation frequency in the placebo group was significantly greater than that in the L. rhamnosus group at weeks 1, 2, 3, and 4. L rhamnosus as a sole treatment was not more effective than placebo in the management of functional constipation in children. This study adds to current recommendations that do not support the use of probiotics in the treatment of childhood constipation.
Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017 Mar 8.
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