Tuesday, June 27, 2017
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments

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Migraine is a neuroinflammatory disorder characterized by recurrent headache attacks. Evidences show TNF-α play a role in neuroimmunity pathogenesis of migraine. TNF-α action resulted in neuro-inflammation and neurogenic pain.

ω-3 fatty acids and curcumin exert neuroprotective and anti-inflammatory effects via several mechanisms including suppression of TNF-α gene expression and its serum levels.


The aim of this study was to assess the synergistic effects of ω-3 fatty acids and nano-curcumin on TNF-α gene expression and serum levels in 74 episodic migraine patients, for 2 months.

A total of 4 groups received either ω-3 fatty acids, nano-curcumin, and combination of them or placebo. The results showed that the combination of ω-3 fatty acids and nano-curcumin downregulated TNF-α mRNA significantly in a synergistic manner (p < 0.05). A significant greater reduction in serum levels of TNF-α were observed in the combination group, but no significant differences in other groups. In addition, a much greater reduction in attack frequency was found in the combination group (p < 0.001).


The fold change of TNF-α gene expression in PBMC extracted mRNA

The fold change of TNF-α gene expression in PBMC extracted mRNA. A much greater reduction has been observed in the combination group. However, based on the Kruskal–Wallis test, these differences in TNF-α fold change among groups are not statistically significant.


These findings indicated that ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.



Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Sedighiyan M, Djalali M, Mohammadzadeh Honarvar N, Djalali M.The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics. 2017 May 6.


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