Tuesday, November 28, 2017

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This study, conducted in mice treated with or without immobilization stress, has examined the effects of Bifidobacterium adolescentis IM38 on anxiety in order to clarify the potential relationship between gut microbiota and anxiety.

Bifidobacterium adolescentis IM38

Oral administration of IM38 at a dose of 1×109 CFU/mouse showed a significant anxiolytic-like effect both in mice exposed to immobilisation stress and in control mice using the elevated plus maze test (p < 0.05).

Moreover, IM38 treatment significantly increased the amount of time spent on open arms and open arm entries. The anxiolytic-like effect of IM38 was comparable to that of buspirone (1 mg/kg). Moreover, this anxiolytic-like effect was blocked by treatment with flumazenil (3 mg/kg, i.p.), a benzodiazepine receptor antagonist.

Therefore, these findings suggest that Bifidobacterium adolescentis IM38 may attenuate anxiety through modulation of the benzodiazepine site on the GABAA receptor.



Jang HM, Jang SE, Han MJ, Kim DH. Anxiolytic-like effect of Bifidobacterium adolescentis IM38 in mice with or without immobilisation stress. Benef Microbes. 2017 Oct 3:1-10.


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