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Thursday, November 29, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This study aim was to determine whether consumption of the soy isoflavones, genistein and daidzein, differentially influence metabolic syndrome. C57BL/6J mice were fed with low fat diet (LF), western-style diet (WD), and WD containing 0.16% (w/w) of genistein (WD + G) or daidzein (WD + D) for 10 weeks.

 

Genistein and daidzein

 

Intake of WD + G and WD + D produced a robust decrease in body weight gain by 40% and 19%, respectively (p < 0.05). Genistein reduced energy intake by 26%, and daidzein decreased energy intake by 8% (p < 0.05). A glucose tolerance test indicated that genistein consumption significantly decreased the incremental areas under the curve (AUC) from 60-120 min, compared to WD-fed mice.

Authors concluded addition of genistein, compared to daidzein, to a western-style diet, more profoundly decreased food intake and body weight gain.

 

Luo T, Miranda-Garcia O, Sasaki G, Wang J, Shay NF. Genistein and daidzein decrease food intake and body weight gain in mice, and alter LXR signaling in vivo and in vitro. Food Funct. 2018 Nov 7.

 

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  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Tuesday, November 27, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this study is to review available data about renal safety of the most prominent amino acid supplements including L-arginine, glutamine and also L-carnitine as well as creatine (as AA derivatives) in athletes and bodybuilders.

Arginine appears to have both beneficial and detrimental effects on kidney function. However, adverse effects are unlikely to occur with the routine doses (from 3 to >100 g/day).

L-carnitine up to 6000 mg/day is generally considered to be a safe supplement at least in healthy adults.

Both short-term (20-30 g within a few hours) and long-term (0.1 g/kg 4 times daily for 2 weeks) glutamine supplementation in healthy athletes were associated with no significant adverse effects, but it can cause glomerulosclerosis and serum creatinine level elevation in the setting of diabetic nephropathy.

Creatine supplementation (ranged from 5 to 30 g/day) also appears to have no detrimental effects on kidney function of individuals without underlying renal diseases.

The pathways of L-arginine biosynthesis and metabolism in humans.

The pathways of L-arginine biosynthesis and metabolism in humans. L-arginine can be metabolized to various compounds through enzymatic pathways. These metabolites can affect many organs of the body including kidney.

Davani-Davari D, Karimzadeh I, Sagheb MM, Khalili H. The Renal Safety of L-Carnitine, L-Arginine, and Glutamine in Athletes and Bodybuilders. J Ren Nutr. 2018 Oct 16.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, November 22, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this experiment was to examine the effects of pineapple juice on high-fat diet-induced obesity in rats. Animals were divided in a control group and a high-fat diet group, and received their allocated diet for 7 weeks. Then, obese animals were divided in three groups: high-fat diet + water, normal diet + pineapple juice, or high-fat diet + pineapple juice. The raw pineapple juice was added to water (15% V/V) and bottles were changed every day.

 

Pineapple juice

 

In comparison to the obese control group, pineapple has reduced body weight and BMI. The pineapple juice also improved liver fat deposition, serum glucose, insulin and plasma lipids levels. The administration of juice downregulated the increment of Fatty Acid Synthase (FAS) and Sterol Regulatory element-Binding Protein-1c (SREBP-1c) mRNA expression in liver, and upregulated Hormone Sensitive Lipase (HSL) and glucose transporter 2 (GLUT-2) expressions.

 

Therefore, this pre-clinical results confer to pineapple a potential anti-obesity effect, which may be explained by a decreased lipogenesis and an increased lipolysis.

 

 

El-Shazly SA, Ahmed MM, Al-Harbi MS, Alkafafy ME, El-Sawy HB, Amer SAM. Physiological and molecular study on the anti-obesity effects of pineapple (Ananas comosus) juice in male Wistar rat. Food Sci Biotechnol. 2018 Apr 11;27(5):1429-1438.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Tuesday, November 20, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, single-blind, parallel-groups study assessed if acute intervention of a flavonoid-rich wild blueberry (WBB) drink boosts executive function (EF), short-term memory and mood 2-6 h post-consumption in 54 7-10-year-old healthy children.

Children consumed a 200 ml WBB drink (253 mg anthocyanins) or a matched placebo. Verbal memory, EF, and reading efficiency were assessed at baseline and 2 h post-consumption.

For the verbal memory, significantly quicker RTs were observed for WBB participants when compared to placebo participants on 120 ms trials, without cost to accuracy (Figure). Furthermore, WBB participants showed enhanced verbal memory performance on the AVLT (Auditory Verbal Learning Task), recalling more words than placebo participants on short delay and memory acquisition measures post-consumption.

 

Mean post-consumption MANT

Mean post-consumption MANT (Modified Attention Network Task) RT scores of placebo and WBB treatment drinks on 120 ms and 500 ms trials. WBB participants perform faster on 120 ms trials than placebo participants.

 

Consumption of WBB was found to significantly improve memory and attentional aspects of EF. This indicates that a flavonoid-rich blueberry product, equivalent to 240 g or 1½ cups of fresh blueberries can provide acute cognitive benefits in children.

 

 

Barfoot KL, May G, Lamport DJ, Ricketts J, Riddell PM, Williams CM. The effects of acute wild blueberry supplementation on the cognition of 7-10-year-old schoolchildren. Eur J Nutr. 2018 Oct 16.

 

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, November 15, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This systematic review focusses on the complementary and alternative medicine for nausea and vomiting in pregnancy. 21 clinical trials have been compiled by the authors, since only studies conducted in Iran have been included. Acupressure and aromatherapy have been found to be effective for the management of nausea.

pregnancy-nausea

Regarding botanicals, 10 studies have examined the effects of ginger, for a total of 1059 participants. All studies have reported the significant beneficial effects of ginger for the management of pregnancy-associated nausea and vomiting. The mechanism of action is unknown, but some authors suggest an action on 5-HT3.

 

In addition, the authors of this systematic review reports that cardamom, 500 mg thrice daily, can reduce nausea and vomiting in pregnant women. However, only one study is available, and these effects should be confirmed by new clinical trials.

 

 

Ozgoli G, Saei Ghare Naz M. Effects of Complementary Medicine on Nausea and Vomiting in Pregnancy: A Systematic Review. Int J Prev Med. 2018 Aug 30;9:75.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87