Nutraveris
Thursday, March 28, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts
Tags:

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, controlled, in vivo study evaluated the effect of 50 mg/kg/d of lutein supplementation during 14 days, on ethanol-induced memory deficits in the object recognition task in adult Wistar rats.

Rats were exposed to ethanol (3 g/kg/d), during 7 days, after 8 days of lutein supplementation.

Ethanol administration induced a memory deficit and increased acetylcholinesterase activity, however, it did not alter the parameters of oxidative stress, evaluated in the cortex and hippocampus. Oral administration of lutein attenuated memory deficit (Figure) and the increase of acetylcholinesterase activity induced by ethanol.

ethanol-induced memory deficits

Effect of administration of lutein (50 mg/kg), ethanol (3g/kg), and the co-administration of ethanol and lutein on the discrimination index in the object recognition task. Data are mean ± SEM, for n = 10-11 animals in each group. * Indicates a significant difference (p < 0.05) compared to the control group (Olive oil/Saline).

 

These results provide evidence that lutein is an alternative treatment for ethanol-induced memory deficit, and suggest the involvement of cholinergic system.

 

Geiss JMT, Sagae S, Paz EDR, de Freitas ML, Souto NS4, Furian AF, Oliveira MS3, Guerra GP. Oral administration of lutein attenuates ethanol-induced memory deficit in rats by restoration of cholinergic function. Physiol Behav. 2019 Feb 14. pii: S0031-9384(18)31017-5.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Leave a Reply