Nutraveris

Category 'News'

Thursday, October 19, 2017

A Tamarindus indica aqueous extract possesses aphrodisiac properties in rats.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

Tamarindus indica is traditionally used in Africa and India for its aphrodisiac properties.

Tamarindus indica

 

In this study, the authors aimed to evaluate the effects of Tamarindus indica in rats.

They used an aqueous extract of fruit pulp. Animals were divided in four groups: control, positive control (sildenafil citrate, 4 mg/kg p.o.), and two T. indica groups (125 or 250 mg/kg p.o.). Parameters were evaluated on day 14, 28, 42 and 54.

Efficacy study showed significant (p < 0.05) improvement in parameters of sexual desire (mount frequency and intromission frequency) and parameters of sexual arousal on all observed days except mount frequency for 125 mg/kg on 42nd day and intromission frequency for both doses of tamarind compared to control. Improvements in these parameters were comparable to the sildenafil. Histopathology study and sperm count suggested an increase in sperm production without any sign of toxicity in testis. Sperm motility significantly (p < 0.05) increased in the treatment groups that received extract at 250mg/kg compared to normal control.

 

This study confirms therefore the potential aphrodisiac properties of T. indica, but also highlight a positive effect on reproductive capacities.

 

Rai A, Das S, Chamallamudi MR, Nandakumar K, Shetty R, Gill M, Sumalatha S, Devkar R, Gourishetti K, Kumar N. Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp. J Ethnopharmacol. 2017 Aug 19. pii: S0378-8741(17)30657-8.

 

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Tuesday, October 17, 2017

Eczema and asthma are common diseases which impact frequently child as the birth. Researchers point out the potential of probiotic consumption to cure children.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

Researchers in recent studies of early probiotic supplementation in infancy have investigated the potential benefit in decreasing the risk of allergic disease such as eczema.

probiotic

The present study aims to evaluate the effects of Lactobacillus rhamnosus supplementation in the cumulative incidence of eczema and asthma in high-risk infants.

To do, researchers design a specific clinical trial involving 159 new-borns. This study was a randomized, double-masked, parallel-arm, controlled trial designed to evaluate the effectiveness of probiotic supplementation for the first 6 months of life to decrease the incidence of eczema, which is a potential early marker of asthma. The intervention arm received a daily capsule of 10 billion colony forming units of Lactobacillus rhamosus and 225 mg of inulin for the first 6 months of life.

 

Infants were accrued over a 6-year period (median follow-up: 4.6 years; 95% retention rate at 2 years). At 2 years of age, the estimated cumulative incidence of eczema was 30.9% (95% confidence interval [CI], 21.4%-40.4%) in the control arm and 28.7% (95% CI, 19.4%-38.0%) in the Lactobacillus rhamosus arm, for a hazard ratio of 0.95 (95% CI, 0.59-1.53) (log-rank P = 0.83). At 5 years of age, the cumulative incidence of asthma was 17.4% (95% CI, 7.6%-27.1%) in the control arm and 9.7% (95% CI, 2.7%-16.6%) in the Lactobacillus rhamosus arm, for a hazard ratio of 0.88 (95% CI, 0.41-1.87) (log-rank P = 0.25)

 

In this study, which included infants with high breastfeeding rates and low cesarean delivery rates, our results do not support the use of early-life Lactobacillus rhamnosus probiotic supplementation for the prevention of asthma or eczema for all children at high risk.   

 

 

Cabana M, Mckean M, Caughey A, Fong L, Lynch S, Wong A, Leong R, Boushey H, Hilton J, Early probiotic supplementation for Eczema and Asthma prevention: a randomized controlled trial. (2017) Pediatrics (in press) .

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.
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Friday, October 13, 2017

Chronic stress is frequently manifested with anxiety and/or depressive symptomatology, which progressively may lead to a spectrum of behavioral and/or somatic disorders. Hops are traditionally used as herbal medicinal product for depression and stress seems to be a good issue.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The effects of a hops on self-reported depression, anxiety and stress levels in young adults remain unclear.

 

Hops

 

The present study aims to evaluate the effects of hops on self-reported depression and anxiety. Researchers design a randomized, placebo-controlled, double-blind, crossover design with two 4-week intervention periods (hops or placebo; two 0.2 gr capsules once daily) separated by a 2-week wash-out. A total of 36 participants reporting themselves a mild depression, anxiety and stress were enrolled.

 

Participant have to complete the Depression Anxiety Stress Scale-21 (DASS-21) at the beginning and the end of the study. Significantly decreased DASS-21 anxiety, depression and stress scores were documented with hops (9.2±7.3 vs. 5.1±5.9, 11.9±7.9 vs. 9.2±7.4, and 19.1±8.1 vs. 11.6±8.1; all p values <0.05), which were significantly greater compared to those caused by the placebo (all p values <0.05).

 

In otherwise healthy young adults reporting at least mild depression, anxiety and stress symptoms, daily supplementation with a hops dry extract can significantly improve all these symptoms over a 4-week period.

These beneficial effects agree with the indication of hops for anxiety/mood disorders and restlessness.

 

 

Kyrou I, Christou A, Panagiotakos D, Stefanaki C, Skenderi K, Katsan K, Tsigos C, Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study (2017) Hormones( (Athens) 16 (2): 171-180

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
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  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Tuesday, October 10, 2017

Inulin-type fructans help in weight management.

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This placebo-controlled study aimed to test the impact of 16 g/d of Inulin-type fructans (ITFs) on appetite and food intake in acute settings.

40 college age females received either a fiber drink with 16 g of ITFs in 330 ml water or placebo. On the 8th day of the study, appetite sensations were assessed using visual analogue scale (VAS) along with food intake.

On the 8th day, the fiber group reported lower ratings for hunger, desire to eat (Figure), and prospective food consumption with significantly higher ratings for satisfaction and fullness. Subsequently, the fiber group consumed 21% less kcal from food at lunch (453 ± 47 kcal) compared to controls (571 ± 39 kcal) (p<0.05).

 

desire to eat

VAS ratings (changes) are shown for desire to eat over 245 min post-breakfast. Intervals are in minutes and indicate time of VAS administration.
Values are mean ± SEM; fiber n = 17, control n = 19.
Significance at *p < 0.05;**p < 0.001.

 

Consuming 16 g/d of ITFs in the morning for 7 days, and after an overnight fast, curbed appetite sensations and helped reduce food intake during lunch meal. These findings highlight the potential of using inulin-type fructans in weight management.

 

Salmean YA. Acute fiber supplementation with inulin-type fructans curbs appetite sensations: a randomized, double-blind, placebo-controlled study. Food Nutr Res. 2017 Jul 2;61(1):1341808.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
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  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, October 5, 2017

Policosanol effects on dyslipidemia: a meta-analysis.

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sugarcane policosanols

The effects of policosanol on blood lipids have been discussed due to discrepancies among clinical studies results.

The purpose of this meta-analysis was to clarify whether sugarcane policosanols were effective and safe for dyslipidemia management.

A total of 22 studies, including 1886 subjects, have been analyzed.

Pooled results showed that, in comparison to placebo, policosanol reduces total cholesterol (-0.58 mmol/L; 95% CI: -0.87 to -0.30 mmol/L, p < 0.0001) and LDL-cholesterol (-0.71 mmol/L; 95% CI: -1.02 to -0.40 mmol/L, p < 0.00001).

No significant effect has been measured regarding triglyceride levels. Conversely, HDL-cholesterol levels have been increased by policosanol (0.13 mmol/L, 95% CI: 0.09 to 0.16 mmol/L, p < 0.00001).

Interestingly, the authors showed that studies conducted in Cuba reported more significant lipid-lowering effects than studies conducted in other countries.

 

Finally, no significant safety concern has been reported. Therefore, policosanol are effective for reducing blood lipid, but more studies are needed to clarify the magnitude of these effects.

 

 

Gong J, Qin X, Yuan F, Hu M, Chen G, Fang K, Wang D, Jiang S, Li J, Zhao Y, Huang Z, Dong H, Lu F. Efficacy and safety of sugarcane policosanol on dyslipidemia: A meta-analysis of randomized controlled trials. Mol Nutr Food Res. 2017 Jul 20.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…
     

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87