Nutraveris

Category 'News'

Thursday, January 17, 2019
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This in vivo study evaluated on atopic dermatitis-like hairless rat model the effects of 0.3 mL of lactic acid bacteria metabolites supplementation during 28 days on water content in the stratum corneum, transepidermal water loss (TEWL), ceramide AP content in the stratum corneum, and epidermis thickness.

Transepidermal water loss (TEWL) and water content of stratum corneum

Transepidermal water loss (TEWL) and water content of stratum corneum in normal rats (Normal), atopic dermatitis-like hairless rat model (Control) and atopic dermatitis-like hairless rat model treated with lactic acid bacteria metabolites (LFP). *** p < 0.001 (Tukey’s post-hoc test).

After supplementation, all measured parameters were improved in atopic dermatitis-like hairless rat model. Author also evaluated components responsible for these effects and showed that water-soluble components and residue obtained after filtration had no effects, whereas the lipid fraction showed similar effects to the raw liquid.

 

In conclusion, lactic acid bacteria metabolites, localized in the lipid fraction, improve skin injury in an atopic dermatitis-like murine model.

 

Tokudome Y. Influence of Oral Administration of Lactic Acid Bacteria Metabolites on Skin Barrier Function and Water Content in a Murine Model of Atopic Dermatitis. Nutrients 2018, 10(12), 1858.

 

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Tuesday, January 15, 2019
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The purpose of this randomized and placebo-controlled study was to examine the effects of a lemon balm supplementation in subjects with type 2 diabetes. 62 patients have been recruited and have received for 12 weeks either a placebo or a lemon balm capsule (1400 mg/day).

Lemon balm

Results showed that lemon balm had significant effects on fasting blood glucose (p = 0.007), HbA1c (p = 0.002), triglycerides (p = 0.04), HDL-cholesterol (p = 0.05), hs-CRP (p = 0.001) and systolic blood pressure (p = 0.04). No change in total and LDL-cholesterol, insulin and insulin sensitivity have been noted.

 

These results suggest that lemon balm may improve the metabolic status of type 2 diabetic patients, reducing probably the risk of cardiovascular diseases.

 

 

Asadi A, Shidfar F, Safari M, Hosseini AF, Fallah Huseini H, Heidari I, Rajab A. Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial. Phytother Res. 2018 Dec 10.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, January 10, 2019
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, double-blinded and placebo-controlled study has been conducted in 48 women with gestational diabetes. They were randomized to receive a capsules contained a placebo or a probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum and Lactobacillus fermentum (2 × 109 CFU/g each) for 6 weeks.

 

gestational diabetes

This supplementation has reduced fasting blood glucose (p = 0.02), serum insulin levels (p = 0.001), and has increased insulin sensitivity (p = 0.001). Moreover, the probiotic supplementation has reduced plasma triglycerides (p = 0.02), VLDL-cholesterol (p = 0.02), and total/HDL-cholesterol ratio (p = 0.006), whereas HDL-cholesterol has been increased (p = 0.03). These effects may be explained at least in part by changes in gene expression, with for instance an increase expression of PPAR-γ (p = 0.01), transforming growth factor beta (p = 0.002) and vascular endothelial growth factor (p = 0.006).

 

Therefore, this clinical study shows that a probiotic supplementation may be an alternative approach for the management of gestational diabetes.

 

 

Babadi M, Khorshidi A, Aghadavood E, Samimi M, Kavossian E, Bahmani F, Mafi A, Shafabakhsh R, Satari M, Asemi Z. The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2018 Dec 8.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Tuesday, January 8, 2019
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This placebo-controlled in vivo study evaluated in gestational rats the effects of safflower oil supplementation of mothers during brain development period (from 14th day of gestation throughout lactation) on the brain electrophysiology and cortical oxidative status in the offspring.

Biomarkers of cortical oxidative status in rats

Biomarkers of cortical oxidative status (in right or left brain part) in rats that were previously raised by mothers which received safflower (SG) or control oil (CG) in their diet during pregnancy and throughout lactation. MDA: Malondialdehyde; SOD: Superoxide dismutase; CAT: Catalase; GST: Glutathione-s-transferase; GSH: Glutathione

 

Offspring from supplemented mothers presented reduction of the cortical spreading depression showing a greater brain excitability compared to placebo group. They also presented a reduction by 39.4% of lipid peroxidation (p < 0.05) compared to placebo. Supplementation reduced superoxide dismutase activity by 40.4% and catalase activity by 64.1% compared to placebo (p < 0.05) but increased activity of glutathione-S-transferase and glutathione level (p < 0.05) compared to placebo.

In conclusion this study demonstrated a long-lasting effect on brain excitability and oxidative stress biomarkers in the offspring born from dams that received safflower oil from the 14th day of gestation until the end of lactation.

 

Mendes-da-Silva RF, Ferreira DJS, Lopes-de-Morais AAC, Cavalcanti de Macêdo PF, Lagranha CJ, Batista-de-Oliveira-Hornsby M. Safflower (Carthamus tinctorius L.) oil during pregnancy and lactation influences brain excitability and cortex oxidative status in the rat offspring. Nutritional Neuroscience. 2017 Aug 04:1-8.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, December 27, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, double-blind, placebo-controlled study aimed to investigated the effects of pro-anthocyanidins from Acacia mearnsii bark extract.

Sixty-six healthy subjects experiencing uncomfortable skin and dry skin symptoms received either Acacia bark extract tablets (containing 245 mg of A. mearnsii proanthocyanidin-equivalent) or placebo for 8 weeks.

 

Variation in transepidermal water loss

Variation in transepidermal water loss on the face in the intervention (black bar, n = 30) and placebo (white bar, n = 30) groups at 8 weeks after intake. Bars display the standard error of the mean.

After 4 weeks, the symptom/feeling score of dermatology life quality index, subjective symptoms related to uncomfortable skin, and the desire to scratch were significantly reduced in the A. mearnsii supplemented group compared to the placebo group. At the end of the experiment, the A. mearnsii supplemented group exhibited significant lower stratum corneum, transepidermal water loss on facial skin compared to the placebo group.

In conclusion, the intake of Acacia mearnsii bark extract reduced skin water loss and improved dry and uncomfortable skin.

 

Hoshino T, Yamashita SI, Suzuki N, Baba A, Ogawa S, Izumi T. Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study. Biosci Biotechnol Biochem. 2018 Dec 10:1-13.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87