This double-blind, randomized placebo-controlled trial has compared the effect of a flavanol-rich chocolate to a control chocolate on endothelial and platelet function in 20 patients with heart failure. The effect of chocolate was assessed in the short-term (2h after ingestion) and long term (4 weeks). Flow-mediated vasodilatation has been increased in the flavanol-rich chocolate group in both short and long term. Conversely, endothelial-independent vasodilatation has not been affected by the supplementations. Platelet adhesion has been reduced 2h after flavanol-rich chocolate, but this effect was not observed after 4 weeks. Consequently, these results highlight cardiovascular beneficial effects of flavanol-rich chocolate.
Eur Heart J. 2012 Sep;33(17):2172-80
Cardiovascular effects of flavanol-rich chocolate in patients with heart failure.
Flammer AJ, Sudano I, Wolfrum M, Thomas R, Enseleit F, Périat D, Kaiser P, Hirt A, Hermann M, Serafini M, Lévêques A, Lüscher TF, Ruschitzka F, Noll G, Corti R