Nutraveris

Category 'News'

Tuesday, September 27, 2016

Antifatigue effect of Abelmoschus esculentus: an in vivo study

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

 

The aim of this study was to determine the antifatigue active fraction from Abelmoschus esculentus.

 

abelmoschus-esculentus

 

360 Kunming male mice were randomly divided into nine subgroups: normal control subgroup, model subgroup, positive subgroup and the ethanol extracts of A. esculentus with high dose (3.2 g/kg) subgroup, medium dose (1.6 g/kg) subgroup and low dose (0.8 g/kg) subgroup, the polysaccharides of high dose (3.2 g/kg) subgroup, medium dose (1.6 g/kg) subgroup, and the low dose (0.8 g/kg) subgroup. Compared with the model subgroup, other subgroups significantly prolonged swimming time, and high dose polysaccharides administration was the most effective (P < 0.01). High dose polysaccharides significantly increased liver glycogen, serum lactic acid, and serum urea (P < 0.01) in mice. In contrast with model group, the high dose polysaccharides administration could also significantly elevated the parameters of testicles and epididymis (P < 0.01). The results demonstrated that both the ethanol extracts and polysaccharides of A. esculentus have antifatigue effects.

  

 Li YX, Yang ZH, Lin Y, Han W, Jia SS, Yuan K. Antifatigue Effects of Ethanol Extracts and Polysaccharides Isolated from Abelmoschus esculentus. Pharmacogn Mag. 2016 Jul-Sep;12(47):219-24..

 

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Thursday, September 22, 2016

Improvement of glycemic control with chamomile

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

 

The objectives of this randomized, single-blind, controlled clinical trial were to investigate the effects of chamomile tea consumption on glycemic control and antioxidant status in 64 subjects, between 30 and 60 years, with type 2 diabetes mellitus.

The supplemented group (n=32) consumed either chamomile tea (3 g/150 mL hot water) 3 times per day immediately after meals or a water regimen (n=32, controlled group) for 8 weeks. Fasting blood samples, anthropometric measurements, and 3-days, 24-h dietary recalls were collected at the baseline and at the end of the trial.

According to the results, chamomile tea significantly decreased concentration of glycosylated hemoglobin, serum insulin levels, homeostatic model assessment for insulin resistance, and serum malondialdehyde, compared with control group (all p < 0.05).

 

graphe-camomille

Figure: Effects of chamomile tea on serum insulin.

Data are present as means ± SE for 32 diabetic patients in each group.

*P < 0.05 for between group comparisons (ANCOVA adjusted for baseline value, intake of oral hypoglycemic agents, and changes of weight and calorie during the study and duration of diabetes).

 

Total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase activities were significantly increased by 6.81%, 26.16%, 36.71% and 45.06% respectively in chamomile group compared with these variables in control group at the end of the intervention (all p < 0.05). In conclusion, short term intake of chamomile tea has beneficial effects on glycemic control and antioxidant status in patients with type 2 diabetes mellitus.

 

Zemestani M, Rafraf M, Asghari-Jafarabadi M. Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus. Nutrition. 2016 Jan;32(1):66-72.

 

This information has been sourced by NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders.

This collaborative and complete tool contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

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Tuesday, September 20, 2016

Andrographis paniculata and andrographolides: not only for upper respiratory tract infection.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. It is acknowledged for its effect on upper respiratory tract infection and recent data show other possible uses.

In recent investigations, this herb was found to be effective against Type 1 diabetes mellitus (Type 1 DM). In a non-genetic out-bred Sprague-Dawley rat model was tested the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Compared to the normal rats, high levels of creatinine, lactate, and allantoin were found in the urine of obese rats, whereas, obese-diabetic rats were marked by high glucose, choline and taurine levels, and low lactate, formate, creatinine, citrate, 2-oxoglutarate, succinate, dimethylamine, acetoacetate, acetate, allantoin and hippurate levels. Treatment of A. paniculata leaf water extract was found to be quite effective in restoring the disturbed metabolic profile of obdb rats back towards normal conditions. This study shows the anti-diabetic potential of A. paniculata plant extract and strengthens the idea of using this plant against the diabetes.

andrographis paniculata

Regarding andrographolides, diterpene of the labdane family obtained from Andrographis paniculata, their effect to recover the cognitive decline was assessed in a rodent model of in a natural model of Alzheimer’s disease. Results suggest that there is an effect of aging on the loss of cognitive function, and this decrease in cognitive function was also related to a decrease in the synaptic functions and an increase in the main hallmarks of Alzheimer’s disease (AD). More importantly, andrographolides treatments showed the following beneficial effects: (1) recovery of spatial memory and learning performance; (2) recovery of synaptic basal transmission; (3) partial or complete protection of certain synaptic proteins; and (4) a specific neuroprotective effect, including the reduction of phosphorylated tau protein and amyloid beta aggregate maturation in aged degus. Taken together, these results suggest that andrographolides could be used as a potential therapy for AD.

 

 

Akhtar MT, Bin Mohd Sarib MS, Ismail IS, Abas F, Ismail A, Lajis NH, Shaari K. Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats. Molecules. 2016;21(8).

 Rivera DS, Lindsay C, Codocedo JF, Morel I, Pinto C, Cisternas P, Bozinovic F, Inestrosa NC. Andrographolide recovers cognitive impairment in a natural model of Alzheimer’s disease (Octodon degus). Neurobiol Aging. 2016 Jul 5;46:204-220.

 

This information has been sourced by NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders.

This collaborative and complete tool contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

More information on www.nutraveris.com

 

Contact our Sientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Tuesday, September 13, 2016

Pomegranate: preclinical studies on bone loss

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

 

Pomegranate has become a leading natural ingredient, recognized by consumer as a super-fruit. Among its various beneficial effects, recent in vivo studies have shown that pomegranate may prevent bone loss. Zhang et al. (2016) have reported that an aqueous pomegranate seed extract can attenuate glucocorticoid-induced bonne loss in mice.

grenade

Pomegranate peel extract may also possess significant beneficial effects. In a preclinical model of osteoporosis, this extract prevented bone loss (-31.9%, p < 0.001 vs. control) and bone microarchitecture impairments (Spilmont et al., 2015). In vitro results suggested that the pomegranate peel extract reduces osteoclast differentiation and bone resorption. Even if human clinical trials are lacking, various other preclinical studies support the use of pomegranate for bone health.

 

 Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Miot-Noirault E, Pilet P, Rios L, Wittrant Y, Coxam V. Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro. Nutrients. 2015 Nov 11;7(11):9265-84.

 Zhang Y, Shao J, Wang Z, Yang T, Liu S, Liu Y, Fan X, Ye W. Aqueous extract of pomegranate seed attenuates glucocorticoid-induced bone loss and hypercalciuria in mice: A comparative study with alendronate. Int J Mol Med. 2016 Aug;38(2):491-8.

 

 This information has been sourced by NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders.

This collaborative and complete tool contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

Formulate new innovative products

Check if your already existing formulas are still compliant with the in force regulations

Adapt your existing formulas to the requirements of other European countries where you are willing to export them

Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Sientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

 

Thursday, September 8, 2016

Sphaeranthus indicus and purple mangosteen for decreasing bodyweight.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, informs you:

 

Overweight troubles are more and more common and efficient solutions are rare. Nevertheless, some plant extracts have beneficial effects on weight loss. In order to help overweight people, a randomized, double-blind, placebo-controlled study assessed the efficacy of Meratrim, a blend of 2 ingredients (plant extracts): flower heads from Sphaeranthus indicus and fruit rinds from purple mangosteen (Garcinia mangostana) in a 3:1 ratio. A total of 60 overweight subjects (mean BMI 28.3 kg/m²) received 800 mg of Meratrim or a placebo for 16 weeks. They consumed about 2000 kcal/day throughout the study period and walk 5 days a week for 30 min daily.

The results of the measured parameters are presented hereunder.

 The results of the measured parameters

At the end of the study, statistically significant reductions were measured in body weight (-5.09 vs. -1.1 kg; p < 0.0001), BMI (-1.91 vs. -0.43 kg/m²; p < 0.0001), waist (-9.97 vs. -3.71 cm; p < 0.001) and hip size (-10.38 vs. -5.11 cm; p < 0.0001) in the Meratrim versus the placebo group. Additionally, a significant change in serum LDL (-14.79 vs. 6.25 mg/dL; p < 0.0001), triglycerides (-43.62 vs. -13.68 mg/dL; p < 0.001) and total cholesterol (-20.0 vs. -0.75 mg/dL; p = 0.0002) was observed in the Meratrim cohort compared to the placebo. No supplementation related adverse events were noted during the study. The study findings suggest that Meratrim is well-tolerated and is an effective ingredient for weight management in healthy overweight subjects.

Kudiganti V, Kodur RR, Kodur SR, Halemane M, Deep DK.

Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects.

Lipids Health Dis. 2016 Aug 24;15(1):136.

 

This information has been sourced by NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders.

This collaborative and complete tool contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
  • It protects your investments since it is updated in real time with reliable quality information analyzed and reviewed by our experts, available hotline.
  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

More information on www.nutraveris.com

Contact our Sientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87