Nutraveris

Category 'News'

Thursday, December 14, 2017

Acute effects of valerian on cortical excitability.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

Valerian is known for its effects on anxiety and sleep disorders. In order to clarify the mechanisms of action of valerian, this randomized, double-blind, placebo-controlled and crossover study examined the acute effect of valerian (900 mg of extract, 0.8% valerenic acid) on cortical excitability assessed with transcranial magnetic stimulation.

 

valerian

 

15 healthy subjects have been enrolled. Measures have been taken 1 and 6h after the oral administration.

The authors reported a significant reduction in intracortical facilitation that return to baseline value 6h after the intake of valerian. No other effect of valerian have been measured.

 

The authors concluded that valerian modulates intracortical facilitatory circuits. However, these results have to be confirmed in patients with anxiety or sleep disorders.

  

 

Mineo L, Concerto C, Patel D, Mayorga T, Paula M, Chusid E, Aguglia E, Battaglia F. Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans. Neuropsychobiology. 2017 Oct 17;75(1):46-51.

 

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Tuesday, December 12, 2017

GINST 15 is food supplement get by enzyme-induced fermentation. Its consequences on inflammatory and hormonal responses remain unknown.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

The purpose of this paper is to explore the constitutive and stress-induced effects of GINST 15 on hypo-pituitary-adrenal (HPA) and oxidant activity.

 

This study was a randomized, double-blind, placebo-controlled counterbalanced within group study.

To do so, ten women (age: 38.7 ± 7.8 years) and nine men (age: 41.2. ± 9.7 years) were enrolled. Participants completed three 14-day treatment cycles with different doses (high: 960 mg; low: 160 mg; placebo: 0 mg) separated by a 1-week washout period. At the end of treatment, physical stress was imposed with intense resistance exercise work stress.

Participants provided blood at rest and various time points after exercise (immediately, 30 min, 60 min, and 24 h). Cortisol, superoxide dismutase, total glutathione, nonspecific antioxidant activity, total antioxidant power, and creatine kinase were measured.

 

Ginseng GINST 15

 

GINST15 supplementation produced stress-inducible dose-dependent reductions in circulating cortisol and increased enzymatic and nonspecific antioxidant activity.

Twenty-four hours after intense exercise, a high dose GINST15, a bioactive ginsenoside metabolite, significantly reduces muscle damage and HPA responses to physical stress in humans; these effects may result from increased antioxidant expression.

 

       

Flanagan SD, DuPont WH, Caldwell LK, Hardesty VH, Barnhart EC, Beeler MK, Post EM, Volek JS, Kraemer WJ.The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress. J Med Food. 2017 Oct 5

 

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With NOL let’s : 

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  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, December 7, 2017

This systematic review points out the recent findings about the link between coffee or caffeine consumption on inflammation.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

Coffee consumption is associated with reduced risk of conditions that share low-grade inflammation as their physiopathological basis.

coffee

 This systematic review summarized the effects of coffee or coffee components on serum levels of inflammatory markers. Clinical trials assessing the effect of coffee, caffeine or other coffee components on inflammatory markers were searched without restriction to publication date. Fifteen studies (8 involving coffee and 7 caffeine) were included.

 

Caffeine

 

Increased adiponectin levels were found in four of seven trials comparing filtered coffee/caffeinated coffee with placebo or comparing its levels at baseline and after consumption of medium or dark roasted coffee, but no change was seen in caffeine trials.

None of the five studies assessing the effects of coffee found changes in C-reactive protein (CPR), but one out of three trials found decreased CPR levels in response to caffeine.

Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies.

Caffeine increased IL-10 levels in two of three trials.

 

These data suggest a predominant anti-inflammatory action of coffee but not of caffeine consumption. To go further, coffee administration over several weeks had a predominant anti-inflammatory effect assessed by serum markers, but caffeine had no clear short-term effect on inflammatory response.

These data suggest that an anti-inflammatory action of coffee consumption may be involved in the protective effect of this beverage on type 2 diabetes risk, and further studies are needed to address whether caffeine or other coffee components underlie this effect. Moreover, the pro-inflammatory and anti-inflammatory responses to caffeine point to its complex effects on the inflammatory response.

       

Clrs P, Bts B, Ceg R, Jg D, Thm C, Aa A Consumption of coffee or caffeine and serum concentration of inflammatory markers: a systematic review. Crit Rev Food Sci Nutr. 2017 Oct 2:0

 

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With NOL let’s : 

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  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Tuesday, December 5, 2017

Common mushroom consumption improves satiety and food intake parameters.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The objective of this randomized, open-label, crossover study was to assess the differences with satiety and 10-day food intake between Agaricus bisporus mushrooms (226 g) and meat (28 g).

 

Common mushroom

32 healthy participants (17 women, 15 men) consumed 2 servings of mushrooms or meat for 10 days.

On the first day, fasted participants consumed protein-matched breakfasts. Participants rated their satiety using visual analogue scales at baseline and at regular intervals after the meal. Participants reported less hunger (p = 0.045), greater fullness (p = 0.05), and decreased prospective consumption (p = 0.03) after the mushroom breakfast.

Mushroom consumption did increase fiber intake on days 1, 2, and 10, but the difference in fiber consumption was only statistically significant on day 2 (p = 0.0001). The mushroom intervention also did not affect energy intake over the 10 day feeding period.

 

Hess JM, Wang Q, Kraft C, Slavin JL. Impact of Agaricus bisporus mushroom consumption on satiety and food intake. Appetite. 2017 Oct 1;117:179-185.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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  • It enables you to be the most responsive with monthly reports and live alerts and a personal use of the information with a report editing tool and customizable bookmarks.

With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, November 30, 2017

Hypoxis hemerocallidea improves fertility in rats.

NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

In this study, the effects of Hypoxis hemerocallidea on male reproductive system have been investigated.

Hypoxis hemerocallidea

Male Wistar rats were treated orally daily for 28 (n = 18) and 56 days (n = 18). Treatment groups (n = 6/group) per treatment period were as follows: untreated control, 150 mg/kg and 300 mg/kg 70% ethanolic extract of Hypoxis hemerocallidea.

Arousal and libido and serum testosterone increased after 56 days of treatment:

Arousal and libido and serum testosterone increased after 56 days of treatment

Effect of treatment with H. hemerocallidea on total serum testosterone, LH and FSH levels (ng/ml) after 56 days of treatment. *p < .05 compared to control

 

There was an increase in epididymal sperm count at both treatment doses, with the 300 mg/kg dose showing a higher sperm count (p < 0.05). The higher dose also showed an increase in sperm motility after 56 days of treatment (p < 0.05). Histology showed an increase in germinal layer thickness, consistent with the observed increase in sperm count.

 

Results suggest that chronic treatment with H. hemerocallidea may improve male sexual function and fertility parameters and may protect testes from oxidative damage.

 

Tiya S, Sewani-Rusike CR, Shauli M. Effects of treatment with Hypoxis hemerocallidea extract on sexual behaviour and reproductive parameters in male rats. Andrologia. 2017 Oct;49(8).

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
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With NOL let’s : 

  • Formulate new innovative products
  • Check if your already existing formulas are still compliant with the in force regulations
  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87