Nutraveris

Category 'NEWS'

Thursday, September 19, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
Tags:

Our Artificial Intelligence solutions, developed by our experts, NOL Datasolution to Create & NOL Compliance to Launch your products, inform you :  

 

Astragalus membranaceus

Astragalus membranaceus

Panax notoginseng roots

Panax notoginseng roots

A blend, of fractionated root extracts of Astragalus membranaceus and Panax notoginseng, InnoSlim®, has been developed for human consumption; however, the unique constituent content of this blend has not been specifically evaluated with respect to safety. Therefore, the toxicological potential of the blend was formally investigated. Toxicity was evaluated in a bacterial reverse mutation test followed by an in vivo mammalian micronucleus test, and general toxicity was evaluated in a 28-day repeated-dose oral toxicity study in rats. 

No evidence of mutagenicity was observed in the bacterial tester strains used, and no evidence of in vivo chromosomal damage resulting in increased frequency of micronucleated cells was observed in male Crl:NMRI BR mice.

No mortality or toxic effects were observed, and no target organs were identified, in male and female Han:WIST rats exposed to 0, 400, 800, or 1200 mg/kg bw/day of the blend by gavage for 28 consecutive days. The highest dose (1200 mg/kg bw/day) was determined to be the NOAEL.

Based on these results, extrapolation towards a safe human consumption level at 6 mg/kg bw/day can be determined, corresponding to 420 mg/day.

 

 

Murbach TS, Glávits R, Endres JR, Hirka G, Vértesi A, Béres E, Szakonyiné IP. Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®). J Toxicol. 2019 Jul 1;2019:5723851.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Tuesday, September 17, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
Tags:

Our Artificial Intelligence solutions, developed by our experts, NOL Datasolution to Create & NOL Compliance to Launch your products, inform you :  

 

Toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE).

 

Safety assessment of mango leaf extract 60% mangiferin.

No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day.

Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han: Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.

 

 

Reddeman RA, Glávits R, Endres JR, Clewell AE, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin. J Toxicol. 2019 Aug 1;2019:4763015.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, September 12, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
Tags:

Our Artificial Intelligence solutions, developed by our experts, NOL Datasolution to Create & NOL Compliance to Launch your products, inform you :  

 

The aim of this study was to examine whether a lycopene supplementation can improve the spermatogram of infertile men with oligozoospermia. 44 men have been enrolled. The study was randomized, double blinded and placebo-controlled. The experimental group received 25 mg/day of lycopene.

Lycopene may improve men’s fertility.

After 12 weeks of supplementation, significant increases in total sperm count and sperm concentration have been measured in the lycopene group. Moreover, in comparison to baseline, lycopene also increased ejaculate volume, total sperm count, sperm concentration and total motility. Total antioxidant capacity has also been affected by the supplementation.

 

Therefore, lycopene may improve fertility in infertile men with oligozoospermia, possibly by modulating oxidative stress.

 

 

Nouri M, Amani R, Nasr-Esfahani M, Tarrahi MJ. The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2019 Aug 30.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Tuesday, September 10, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
Tags:

Our Artificial Intelligence solutions, developed by our experts, NOL Datasolution to Create & NOL Compliance to Launch your products, inform you :  

 

In this randomized, double-blind controlled study, 30 healthy subjects were daily supplemented with either 1 mg or 30 mg of lycopene or 7mg of lycopène plus 10 g of dark chocolate or 10 g of dark chocolate. Supplementation was performed during 1 month.

Results of the study showed that by the end of the trial there were dose-dependent changes in the gut microbiota profile in all lycopene groups with an increase of relative abundance of Bifidobacterium adolescentis and Bifidobacterium longum. This was also accompanied by dose-dependent changes in the blood, liver metabolism, skeletal muscle and skin parameters. Consumption of dark chocolate resulted in increased relative abundance of Lactobacillus genus and a reduction of corneocyte exfoliation.

Dark chocolate and lycopene present prebiotic potential and improve blood, liver, muscle and cutaneous parameters in healthy individuals.

Changes in skin parameters after supplementation with 7 mg of lycopene for one month. Typical skin smear samples: lipid droplets of the sebum were stained with Oil Red O, and corneocytes with hematoxylin, eosin at 1,000× magnification.

In conclusion, systemic effect of lycopene or dark chocolate, including improvement of gut, blood, liver lipid metabolism and, skeletal muscles and skin parameters could be not just due to the carotenoid and dark chocolate properties themselves, but are likely also to modulate the gut microbiome increasing the relative abundance of putatively beneficial bifidobacteria and lactobacilli.

 

Wiese M, Bashmakov Y, Chalyk N, Nielsen DS, Krych Ł, Kot W, Klochkov V, Pristensky D, Bandaletova T, Chernyshova M, Kyle N, Petyaev I. Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons. Biomed Res Int. 2019 Jun 2;2019:4625279.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, September 5, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
Tags:

Our Artificial Intelligence solutions, developed by our experts, NOL Datasolution to Create & NOL Compliance to Launch your products, inform you :  

This randomized, double-blind, parallel controlled trial investigated the effects of daily consumption of coffee enriched in chlorogenic acids (CGA) on abdominal fat area. Healthy, overweight men and women (n = 150, BMI ≥ 25 to <30 kg/m²) were allocated to high-CGA (369 mg CGA/serving) or control (35 mg CGA/serving) coffee groups. Instant coffee was consumed once daily for 12 weeks, with four-week pre- and post-observation periods. Abdominal fat area and anthropometric measurements were analyzed at baseline and at 4, 8, and 12 weeks, and 142 subjects completed the trial.

A new clinical trial shows the beneficial effects of green coffee: chlorogenic acid decreases abdominal fat and BMI.

 

Visceral fat area (VFA), total abdominal fat area (TFA), body weight, and waist circumference significantly decreased in the CGA group compared with the control group, with a group x time interaction (p < 0.001, p = 0.001, p = 0.025, and p = 0.001, respectively). Changes in VFA and TFA from baseline to 12 weeks were significantly greater in the CGA group than in the control group (-9.0 ± 13.9 cm² vs. -1.0 ± 14.3 cm², p < 0.001; -13.8 ± 22.9 cm² vs. -2.0 ± 16.2 cm², p < 0.001).

Consumption of high-CGA coffee for 12 weeks by overweight adults might lower abdominal fat, BMI, and waist circumference.

 

Watanabe T, Kobayashi S, Yamaguchi T, Hibi M, Fukuhara I, Osaki N. Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial. Nutrients. 2019 Jul 16;11(7).

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87