Nutraveris

Category 'INGREDIENTS'

Thursday, September 20, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized study hypothesized that garlic, coriander and their mixture improves the lipid profile, BMI and blood pressure of 80 hyperlipidemic patients. The groups were randomly assigned to 3 supplements: garlic powder, coriander seed powder, mixture and placebo at a dose rate of 2 g/day, for 40 days.

Garlic
coriander

The results indicated that all the supplements significantly (p<0.05) influenced the BMI, HDL, total cholesterol, triglycerides, LDL and systolic blood pressure of the patients. Among the supplements, garlic powder had the highest influenced on BMI, TC, LDL and HDL whereas the impact of the mix garlic powder and coriander seed powder, and coriander seed powder was more pronounced on TGL and blood pressure of the patients, respectively. All the parameters decreased with supplementation except HDL, which increased with the consumption of supplements.

It was concluded that consumption of garlic, coriander and their mixture at a dose rate of 2 g/day is improving the lipid parameters of the patients.

 

Zeb F, Safdar M, Fatima S, Khan S, Alam S, Muhammad M, Syed A, Habib F, Shakoor H. Supplementation of garlic and coriander seed powder: Impact on body mass index, lipid profile and blood pressure of hyperlipidemic patients. Pak J Pharm Sci. 2018 Sep;31(5):1935-1941.

 

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Tuesday, September 18, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

Glucosamine is widely used for the management of joint disorders. The purpose of this randomized, double-blinded and placebo-controlled study was to evaluate the chondroprotective effects of glucosamine in soccer players without joint disorders (healthy subjects).

cartilage degeneration in soccer player

43 subjects received 2 g/day of glucosamine or a placebo for 16 weeks. Cartilage metabolism was evaluated by analyzing markers of type II collagen degradation (urine C-terminal telopeptide II (CTX-II) and serum collagen type II cleavage (C2C)) and synthesis (urine c-terminal type II procollagen peptide (CPII)). Urine CTX-II levels decreased in the glucosamine group but not in the placebo group (p = 0.05). Moreover, serum C2C level significantly decreased in the supplemented group in comparison to placebo (p < 0.05). Conversely, urine CPII levels were not affected by glucosamine.

 

In conclusion, glucosamine exert a chondroprotective effect in soccer players, mainly by reducing cartilage degeneration. However, the clinical significance of such effect in these healthy subjects remains to be clarified.

 

 

Tsuruta A, Horiike T, Yoshimura M, Nagaoka I. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study. Mol Med Rep. 2018 Aug 17.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

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Thursday, September 13, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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This randomized, double-blind crossover study aimed to evaluate the effects of grape powder ingestion on measures of HDL function in adults with metabolic syndrome.

Grape powder

 

Twenty adults (age: 32-70 years; BMI: 25.3-45.4 kg/m²) consumed either 60 g/day of freeze-dried grape powder (GRAPE) or a placebo, for 4 weeks. The primary outcome was serum paraoxonase-1 (PON1) arylesterase activity, a measure of HDL antioxidant function.

After 4 weeks, GRAPE did not alter the serum PON1 activity or other markers of HDL function compared with placebo. Measures of HDL function were positively correlated with each other and inversely with measures of insulin resistance and inflammation. GRAPE intake led to a significant reduction in fasting plasma triglycerides compared with placebo (P = 0.032).

Grape powder consumption did not impact HDL function in this cohort of adults with metabolic syndrome. However, it was shown to improve fasting triglycerides, a risk factor for cardiovascular disease.

 

 

Millar CL, Duclos Q, Garcia C, Norris GH, Lemos BS, DiMarco DM, Fernandez ML, Blesso CN. Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein Function in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Study. Metab Syndr Relat Disord. 2018 Aug 21.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

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Tuesday, September 11, 2018
Category : News, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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This aim of this pilot study was to examine the effects of a novel proprietary delivery form of quercetin (Phytosome®) in amateur triathlon athletes. 48 subjects have been enrolled. They received no supplement (n = 25) or 250 mg Phytosome® twice daily for 14 days. The training included repetition of a run 8 times in 14 days.

triathlon athletes

Results showed an improvement in the time to complete the run in the supplemented group in comparison to control (-11.3% vs. -3.9%, p < 0.05). Moreover, training was considered as more valuable in the quercetin group in comparison to control (p < 0.05). In addition, post-run muscular pain, cramps, localized pain and post-exercise recovery time was all considered better with the supplementation (p < 0.05).

 

Therefore, this pilot study suggest that Phytosome® may improve physical performance in athletes. These results should be confirmed in larger well-designed clinical trials.

 

 

Riva A, Vitale JA, Belcaro G, Hu S, Feragalli B, Vinciguerra G, Cacchio M, Bonanni E, Giacomelli L, Eggenhöffner R, Togni S. Quercetin phytosome® in triathlon athletes: a pilot registry study. Minerva Med. 2018 Aug;109(4):285-289.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
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  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, September 6, 2018
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this work was to investigate whether raspberry consumption can improve vascular function and to understand which phenolic metabolites may be responsible for the effects.

A 3 arm double-blind randomized controlled crossover human intervention trial was conducted in 10 healthy males. Flow-mediated dilation (FMD) was measured at baseline, 2 h, and 24 h post-consumption of 200 g and 400 g of red raspberries containing 201 or 403 mg of total (poly)phenols, or a matched control drink.

 

Raspberries

 

Raspberry (poly)phenol metabolites were analyzed in plasma and urine by UPLC-QTOF mass spectrometry using authentic standards. Significant improvements in FMD were observed at 2 h (1.6% (95%CI 1.2, 1.9) and 1.2% (95% CI 0.8, 1.5)) and 24 h (1.0% (95% CI 0.6, 1.2) and 0.7% (95%CI 0.2, 0.9)) post-consumption of the 200 and 400 g raspberry drinks as compared to control, respectively. Plasma ellagic acid, urolithin A-3-glucuronide and urolithin A-sulfate correlated with the improvements in FMD at 2 and 24 h post consumption, respectively.

Consumption of dietary achievable amounts of red raspberries acutely improves endothelial function up to 24 h and ellagitannins may be responsible for the observed effect.

 

 

Istas G, Feliciano RP, Weber T, Garcia-Villalba R, Tomas-Barberan F, Heiss C, Rodriguez-Mateos A  Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial. Arch Biochem Biophys. 2018 Aug 1;651:43-51.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

  • It solves all regulatory issues since it contains the required information on all ingredients authorized in the 28 European member states…on regulatory status, health claims, authority opinions
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With NOL let’s : 

  • Formulate new innovative products
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  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87