Nutraveris

Category 'CLINICAL EVIDENCE'

Thursday, April 25, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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This pilot clinical study, aimed to determine the effects of daily supplementation during 6 months with 1×108 CFU of Lactobacillus salivarius PS7, selected for its antagonism of otophathogens, in the prevention of otitis in 61 children suffering of recurrent acute otitis media.

 

Supplementation with Lactobacillus salivarius prevents recurrent acute otitis in children.

Comparison between the number of AOM episodes reported during the 6 months of the probiotic treatment and those reported during the previous 6 months. **, statistically significant change (p < 0.05; ¬χ2 test).

Thirty six percent (36%) of the recruited children suffered at least one episode of acute otitis media, with a median duration of 4 days. In contrast, 70% of the children with recurrent acute otitis media who were attended by the same pediatrician in the same period but did not receive the probiotic strain suffered at least one acute otitis media episode with a median duration of 6 days. The number of acute otitis media episodes during the 6-month intervention period decreased by 84% when compared to the number registered in the 6 months that preceded the intervention (Figure 1). Moreover, the microbial density in the external auditory canal decreased notably along the intervention period, from >3.5 log10 CFU at the baseline (all the cultures were positive at this sampling time) to <2 log10 CFU at the end of the intervention (with 22% of the cultures being negative).

In conclusion, Lactobacillus salivarius PS7 is a promising strain for the prevention of recurrent acute otitis media in infants and children.

 

Cárdenas N, Martín V, Arroyo R, López M, Carrera M, Badiola C, Jiménez E, Rodríguez JM. Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain. Nutrients. 2019 Feb 12;11(2).

 

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Thursday, April 18, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The aim of this randomized, double-blind and placebo-controlled trial was to investigate the efficacy and safety of Nigella sativa seed oil in the treatment of patients with non-alcoholic fatty liver disease (NAFLD).

To do so, 120 patients with non-alcoholic fatty liver disease were randomized to receive either 2.5mL of a fully standardized N. sativa seed oil every 12h or a placebo for 3 months.

Beneficial effect of Nigella sativa supplementation on non-alcoholic fatty liver disease.

 

Results showed that grade of hepatic steatosis was significantly reduces in the oil group compared to the placebo (p = 0.004). Moreover, triglycerides, LDL-C and HDL-C were significantly decreased compared to placebo (p = 0.001, p = 0.01, p = 0.001 respectively). However, the oil did not significantly affect the other outcome variables compared to the placebo (all p > 0.05).

Authors concluded that Nigella sativa seed oil seems to be safe and improve liver disorders in the NAFLD patients.

 

Khonche A, Huseini HF, Gholamian M, Mohtashami R, Nabati F, Kianbakht S. Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial. J Ethnopharmacol. 2019 Apr 24;234:106-111.

 

 

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Thursday, April 11, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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This randomized, single-blind, placebo-controlled study evaluated among 70 women with acute uncomplicated cystitis the effects of daily supplementation during 3 days with 2000 mg of spray-dried aqueous extract of green tea or placebo (Starch) along with antibiotherapy (trimethoprim-sulfamethoxazole).

 Green tea as adjunctive therapy for acute uncomplicated cystitis in women

Women in the green tea group showed a decrease in the prevalence of cystitis symptoms compared to baseline, from 68% to 61% after 1 day, to 34% after 2 days and to 2% after 3 days. This prevalence of cystitis symptoms decrease is significantly higher in the green tea group than in the placeob group at all measurement point (all p < 0.01). Also a significant improvement in urinalysis results (abnormal urine color, pyuria, bacteruria, all p < 0.0001) were noted in the green tea group compared to the placebo group after 3 days of supplementation.

 

Authors concluded that green tea extract is efficient as adjunctive therapy for the management of cystitis symptoms in women with acute uncomplicated cystitis.

 

Kheirabadi Z, Mehrabani M, Sarafzadeh F, Dabaghzadeh F, Ahmadinia N. Green tea as an adjunctive therapy for treatment of acute uncomplicated cystitis in women: A randomized clinical trial. Complementary Therapies in Clinical Practice 34 (2019) 13–16

 

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With NOL let’s : 

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  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, April 4, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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This randomized, double-blinded and placebo-controlled trial has evaluated the effects of green cardamom (3 g/day for 10 weeks) in 83 overweight or obese type 2 diabetic patients. The authors examined the effects of the supplementation in anthropometric parameters, glycemic indices and blood lipids. Serum sirtuin-1 level has also been assessed.

Cardamon

In comparison to the placebo, green cardamom has reduced plasma HbA1c (-0.4%), insulin (-2.8 µIU/dL) and triglycerides (-39.9 mg/dL). Moreover, an improvement in insulin sensitivity has been noted, highlighted by the reduction in the HOMA-IR indice (-1.7). Finally, an increase in sirtuin-1 level has been measured.

 

The authors concluded that green cardamom may improve some metabolic parameters in overweight or obese type 2 diabetic patients by increasing the Sirtuin-1 level.

 

 

Aghasi M, Koohdani F, Qorbani M, Nasli-Esfahani E, Ghazi-Zahedi S, Khoshamal H, Keshavarz A, Sotoudeh G. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agric. 2019 Jan 30.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
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  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

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Thursday, March 28, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, controlled, in vivo study evaluated the effect of 50 mg/kg/d of lutein supplementation during 14 days, on ethanol-induced memory deficits in the object recognition task in adult Wistar rats.

Rats were exposed to ethanol (3 g/kg/d), during 7 days, after 8 days of lutein supplementation.

Ethanol administration induced a memory deficit and increased acetylcholinesterase activity, however, it did not alter the parameters of oxidative stress, evaluated in the cortex and hippocampus. Oral administration of lutein attenuated memory deficit (Figure) and the increase of acetylcholinesterase activity induced by ethanol.

ethanol-induced memory deficits

Effect of administration of lutein (50 mg/kg), ethanol (3g/kg), and the co-administration of ethanol and lutein on the discrimination index in the object recognition task. Data are mean ± SEM, for n = 10-11 animals in each group. * Indicates a significant difference (p < 0.05) compared to the control group (Olive oil/Saline).

 

These results provide evidence that lutein is an alternative treatment for ethanol-induced memory deficit, and suggest the involvement of cholinergic system.

 

Geiss JMT, Sagae S, Paz EDR, de Freitas ML, Souto NS4, Furian AF, Oliveira MS3, Guerra GP. Oral administration of lutein attenuates ethanol-induced memory deficit in rats by restoration of cholinergic function. Physiol Behav. 2019 Feb 14. pii: S0031-9384(18)31017-5.

 

This information has been sourced by NOL, a collaborative and complete tool which contains all Regulatory, Scientific and Marketing data

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With NOL let’s : 

  • Formulate new innovative products
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  • Adapt your existing formulas to the requirements of other European countries where you are willing to export them
  • Do scientific & regulatory & marketing monitoring which enable to anticipate the withdrawal of products, the safety issues, new interesting scientific studies, the arrival of new players on the market…

 

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87