Nutraveris

Category 'CLINICAL EVIDENCE'

Thursday, August 1, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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A parallelized, randomized clinical study with 31 young healthy adults investigated the effects of a glucose solution (control group) or a glucose solution containing a guava fruit extract prepared by supercritical CO2 extraction (intervention group), during an oral glucose tolerance test (OGTT).

Guava fruit extract inhibits intestinal glucose resorption

Blood samples were collected prior to and up to 2 hours after glucose consumption to quantitate blood glucose and insulin levels.

The results show that, in comparison to the control group, consumption of guava fruit extract resulted in a significantly reduced increase in postprandial glucose response over the basal fasting plasma glucose levels after 30 min (Δ control 2.60 ± 1.09 mmol/L versus Δ intervention 1.96 ± 0.96 mmol/L; p = 0.039) and 90 min (Δ contr. 0.44 ± 0.74 mmol/L versus Δ inter. -0.18 ± 0.88 mmol/L; p = 0.023). In addition, a slightly reduced, but non-significant insulin secretion (p = 0.302) was observed. Interestingly, storage time and repeated freeze-thawing operations appeared to negatively influence the efficacy of the applied extract.

Several substances at relevant concentrations including kojic acid (0.33 mg/mL) and 5-hydroxymethylfurfural (2.76 mg/mL) were identified as bioactive compounds.

This clinical trial confirms the efficacy of the guava fruit extract in inhibiting intestinal glucose resorption, possibly in combination with reduced insulin secretion. Based on these findings, this extract appears promising for patients with diabetes and for the prevention of insulin resistance.

 

König A, Schwarzinger B, Stadlbauer V, Lanzerstorfer P, Iken M, Schwarzinger C, Kolb P, Schwarzinger S, Mörwald K, Brunner S, Höglinger O, Weghuber D, Weghuber J. Guava (Psidium guajava) Fruit Extract Prepared by Supercritical CO(2) Extraction Inhibits Intestinal Glucose Resorption in a Double-Blind, Randomized Clinical Study. Nutrients. 2019 Jul 3;11(7).

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

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Thursday, July 25, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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Some studies have suggested that watermelon could have beneficial effects on obesity and obesity-related disorders. However, the demonstration of the efficacy of watermelon is lacking. This crossover study compared the effects of watermelon (2 cups/day) to isocaloric low-fat cookies in 33 overweight or obese subjects.

Watermelon has satiety effects and reduces some cardiovascular risk factors in obese or overweight subjects.

After 4 weeks of supplementation, watermelon had higher effects on satiety than cookies (lower hunger, prospective food consumption and desire to eat and greater fullness, p < 0.05). Watermelon consumption significantly decreased body weight, body mass index, systolic blood pressure and waist-to-hip ratio (p < 0.05).

 

Therefore, this study demonstrates for the first time that watermelon consumption has beneficial effects on metabolic health of overweight or obese subjects, with notably a satiety effect, and reductions in body weight and blood pressure.

 

 

Lum T, Connolly M, Marx A, Beidler J, Hooshmand S, Kern M, Liu C, Hong MY. Effects of Fresh Watermelon Consumption on the Acute Satiety Response and Cardiometabolic Risk Factors in Overweight and Obese Adults. Nutrients. 2019 Mar 12;11(3).

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

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Thursday, July 18, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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Since several years, many health benefits have been conferred to avocado. Recently, two new studies have provided new evidences of such benefits, with improvements in cognition function and modulation of gut microflora following consumption of fresh avocado.

Avocado: a fruit with various health benefits

In a randomized and controlled trial, Edwards et al. (2019) have shown that one avocado per day for 12 weeks was able to improve selective attention and serum lutein concentrations in adults with overweight or obesity (n = 72). No change in macular pigment optical density has been measured in this study.

The same research team has also examined the effects of fresh avocado (1 per day for 12 weeks on gut microflora still in overweight or obese subjects (n = 160) (Thompson et al., 2019). The avocado intake was associated with increased acetate and total short-chain fatty acid concentrations, and with increased relative abundance of Faecalibacterium.

 

Therefore, avocado consumption may have beneficial effects on gastrointestinal health and cognitive function, confirming the interest of this fruit.

 

Edwards C, Walk A, Thompson S, Reeser G, Erdman J Jr, Burd N, Holscher H, Kha N. Effects of a 12-week Avocado Randomized-controlled Trial on Cognitive Function and Lutein Status Among Adults with Overweight and Obesity (OR05-01-19). Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz029.OR05-01-19.

Thompson S, Edwards C, Reeser G, Khan N, Holscher H. Effects of Avocado Consumption on Gastrointestinal Microbial Metabolite Concentrations and Taxa Abundances: A Randomized, Controlled Trial (OR23-07-19). Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz040.OR23-07-19.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, July 11, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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The aim of this randomized, double-blinded and placebo-controlled study was to examine the effects of green cardamom (3 g/day for 3 months) in overweight or obese patients with non-alcoholic fatty liver disease (NAFLD). The authors assessed the effects of cardamom on glucose metabolism, insulin sensitivity, blood lipids, and irisin levels.

Green cardamom improves metabolism of obese subjects with non-alcoholic fatty liver disease.

Compared to placebo, the cardamom supplementation increased irisin, HDL-cholesterol and insulin sensitivity. It also reduced fasting blood insulin, triglycerides, LDL-cholesterol, and the grade of fatty liver (p < 0.05). No change in fasting blood glucose, total cholesterol and BMI have been noted.

 

These results suggest therefore that green cardamom can be beneficial for overweight or obese subjects with NAFLD.

 

Daneshi-Maskooni M, Keshavarz SA, Qorbani M, Mansouri S, Alavian SM, Badri-Fariman M, Jazayeri-Tehrani SA, Sotoudeh G. Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind, randomized placebo-controlled clinical trial. BMC Complement Altern Med. 2019 Mar 12;19(1):59.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87

Thursday, July 4, 2019
Category : NEWS, INGREDIENTS, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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This randomized and placebo-controlled study examined the effects of Phyllanthus amarus for the management of hangover symptoms. 15 subjects have been enrolled and received for 10 days a placebo or 750 mg/day of PHYLLPRO®, A P. amarus leaf extract, before alcohol intoxication.

Efficacy of Phyllanthus amarus for reducing hangover symptoms.

The supplementation accelerated alcohol removal from blood in comparison to placebo at 12-hour post-intoxication (p < 0.0001). The Hangover Severity Score showed lower hangover symptoms in the active group, whereas nausea, headache, anorexia, tremulousness, diarrhea and dizziness were noted in the placebo group (p < 0.05). Higher fatigue and tension were also noted in the placebo group. The assessment of cytokines showed an anti-inflammatory effect of P. amarus.

 

Therfeore, this small pilot study suggests that a P. amarus leaf extract can reduce hangover symptoms, partly by preventing alcohol-induced inflamamation.

 

 

George A, Udani JK, Yusof A. Effects of Phyllanthus amarus PHYLLPROTM leaves on hangover symptoms: a randomized, double-blinded, placebo-controlled crossover study. Pharm Biol. 2019 Dec; 57(1):145-153.

 

NUTRAVERIS is the Leading European consultancy on Regulatory & Scientific affairs in Nutrition and Health, founded 13 years ago, to help you formulate, ensure the compliance and substantiation of your products in the 28 EU Member States. 

Thanks to our strong know-how and experience of regulatory compliance, notifications, novel foods, health claims, medical writing,…We, as experts, created Artificial Intelligence solutions, that we use in our everyday missions:
-NOL Datasolution to CREATE new products thanks to Regulatory, Scientific & Marketing data.
-NOL Compliance to LAUNCH products into the different EU member states thanks to automated Compliance analysis, Labeling generation and Monitoring & updating at anytime.

More information on www.nutraveris.com

Contact our Scientific & Regulatory experts at NUTRAVERIS

contact@nutraveris.com, +33 2 96 76 54 87