Nutraveris
Tuesday, January 15, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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The purpose of this randomized and placebo-controlled study was to examine the effects of a lemon balm supplementation in subjects with type 2 diabetes. 62 patients have been recruited and have received for 12 weeks either a placebo or a lemon balm capsule (1400 mg/day).

Lemon balm

Results showed that lemon balm had significant effects on fasting blood glucose (p = 0.007), HbA1c (p = 0.002), triglycerides (p = 0.04), HDL-cholesterol (p = 0.05), hs-CRP (p = 0.001) and systolic blood pressure (p = 0.04). No change in total and LDL-cholesterol, insulin and insulin sensitivity have been noted.

 

These results suggest that lemon balm may improve the metabolic status of type 2 diabetic patients, reducing probably the risk of cardiovascular diseases.

 

 

Asadi A, Shidfar F, Safari M, Hosseini AF, Fallah Huseini H, Heidari I, Rajab A. Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial. Phytother Res. 2018 Dec 10.

 

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Thursday, January 10, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, double-blinded and placebo-controlled study has been conducted in 48 women with gestational diabetes. They were randomized to receive a capsules contained a placebo or a probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum and Lactobacillus fermentum (2 × 109 CFU/g each) for 6 weeks.

 

gestational diabetes

This supplementation has reduced fasting blood glucose (p = 0.02), serum insulin levels (p = 0.001), and has increased insulin sensitivity (p = 0.001). Moreover, the probiotic supplementation has reduced plasma triglycerides (p = 0.02), VLDL-cholesterol (p = 0.02), and total/HDL-cholesterol ratio (p = 0.006), whereas HDL-cholesterol has been increased (p = 0.03). These effects may be explained at least in part by changes in gene expression, with for instance an increase expression of PPAR-γ (p = 0.01), transforming growth factor beta (p = 0.002) and vascular endothelial growth factor (p = 0.006).

 

Therefore, this clinical study shows that a probiotic supplementation may be an alternative approach for the management of gestational diabetes.

 

 

Babadi M, Khorshidi A, Aghadavood E, Samimi M, Kavossian E, Bahmani F, Mafi A, Shafabakhsh R, Satari M, Asemi Z. The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2018 Dec 8.

 

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Tuesday, January 8, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This placebo-controlled in vivo study evaluated in gestational rats the effects of safflower oil supplementation of mothers during brain development period (from 14th day of gestation throughout lactation) on the brain electrophysiology and cortical oxidative status in the offspring.

Biomarkers of cortical oxidative status in rats

Biomarkers of cortical oxidative status (in right or left brain part) in rats that were previously raised by mothers which received safflower (SG) or control oil (CG) in their diet during pregnancy and throughout lactation. MDA: Malondialdehyde; SOD: Superoxide dismutase; CAT: Catalase; GST: Glutathione-s-transferase; GSH: Glutathione

 

Offspring from supplemented mothers presented reduction of the cortical spreading depression showing a greater brain excitability compared to placebo group. They also presented a reduction by 39.4% of lipid peroxidation (p < 0.05) compared to placebo. Supplementation reduced superoxide dismutase activity by 40.4% and catalase activity by 64.1% compared to placebo (p < 0.05) but increased activity of glutathione-S-transferase and glutathione level (p < 0.05) compared to placebo.

In conclusion this study demonstrated a long-lasting effect on brain excitability and oxidative stress biomarkers in the offspring born from dams that received safflower oil from the 14th day of gestation until the end of lactation.

 

Mendes-da-Silva RF, Ferreira DJS, Lopes-de-Morais AAC, Cavalcanti de Macêdo PF, Lagranha CJ, Batista-de-Oliveira-Hornsby M. Safflower (Carthamus tinctorius L.) oil during pregnancy and lactation influences brain excitability and cortex oxidative status in the rat offspring. Nutritional Neuroscience. 2017 Aug 04:1-8.

 

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Thursday, December 27, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, double-blind, placebo-controlled study aimed to investigated the effects of pro-anthocyanidins from Acacia mearnsii bark extract.

Sixty-six healthy subjects experiencing uncomfortable skin and dry skin symptoms received either Acacia bark extract tablets (containing 245 mg of A. mearnsii proanthocyanidin-equivalent) or placebo for 8 weeks.

 

Variation in transepidermal water loss

Variation in transepidermal water loss on the face in the intervention (black bar, n = 30) and placebo (white bar, n = 30) groups at 8 weeks after intake. Bars display the standard error of the mean.

After 4 weeks, the symptom/feeling score of dermatology life quality index, subjective symptoms related to uncomfortable skin, and the desire to scratch were significantly reduced in the A. mearnsii supplemented group compared to the placebo group. At the end of the experiment, the A. mearnsii supplemented group exhibited significant lower stratum corneum, transepidermal water loss on facial skin compared to the placebo group.

In conclusion, the intake of Acacia mearnsii bark extract reduced skin water loss and improved dry and uncomfortable skin.

 

Hoshino T, Yamashita SI, Suzuki N, Baba A, Ogawa S, Izumi T. Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study. Biosci Biotechnol Biochem. 2018 Dec 10:1-13.

 

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Tuesday, December 25, 2018
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized open-label crossover study  evaluated among 32 healthy adults the effects of mushroom (Agaricus bisporus) consumption twice daily for ten days, compared to meat consumption, on gastrointestinal tolerance, short chain fatty acid (SCFA) production, laxation, and fecal microbiota composition.

No differences in breath hydrogen, stool frequency, consistency, fecal pH, or SCFA concentrations between the two diets were noted, but the mushroom diet led to greater overall gastrointestinal symptoms than the meat diet on days one and two. The mushroom-rich diet resulted in higher average stool weight (p = 0.002) and a different fecal microbiota composition compared to the meat diet, with greater abundance of Bacteroidetes (p = 0.0002) and lower abundance of Firmicutes (p = 0.0009).

Laxation markers for fecal samples collected days 6 through 10.

Laxation markers for fecal samples collected days 6 through 10.

In conclusion, mushroom consumption may impact laxation in healthy adults and affect the gut microbiota.

 

Hess J., Wang Q., Gould T. and Slavin J. Impact of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy Adults. Nutrients 2018, 10, 1402.

 

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