Nutraveris
Thursday, December 28, 2017
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

The purpose of this paper is to investigate the effect of probiotic Lactobacillus casei Shirota on patients with knee osteoarthritis.

Lactobacillus casei Shirota 

 

This study was a randomized, double-blind, placebo-controlled study. To do so, 537 patients with knee osteoarthritis were enrolled and received skimmed milk containing either Lactobacillus casei Shirota or placebo daily for 6 months.

Primary outcome was defined as changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analog scale (VAS) scores. Secondary outcome was defined as changes in serum levels of high sensitivity C-reactive protein (hs-CRP).

The main results show after 6 months a significantly improvement of both WOMAC and VAS score in the Lactobacillus casei Shirota group compared to the placebo group. Moreover, serum levels of hs-CRP levels were also significantly improved in the Lactobacillus casei Shirota consumption.

 

To conclude, the main findings of this clinical study were a daily dose of 1.2×1010 cfu Lactobacillus casei Shirota could improve treatment outcome of knee osteoarthritis, possibly by reducing serum levels of hs-CRP, an inflammation response factor frequently elevated in musculoskeletal disorders.

       

Lei M, Guo C, Wang D, Zhang C, Hua L, The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial. Benef Microbes. 2017 Oct 13;8(5):697-703

 

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Tuesday, December 26, 2017
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This meta-analysis was performed to assess the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD). The analysis included 7 eligible studies (649 patients).

 

Turmeric and curcumin in lowering blood lipid levels

 

Turmeric and curcumin significantly reduced serum LDL-C (SMD = -0.340, 95% confidence interval [CI]: -0.530 to -0.150, P < 0.0001) and TG (SMD = -0.214, 95% CI: -0.369 to -0.059, P = 0.007) levels as compared to those in the control group.

These may be effective in lowering serum TC levels in patients with metabolic syndrome (MetS, SMD = -0.934, 95% CI: -1.289 to -0.579, P < 0.0001), and turmeric extract could possibly have a greater effect on reducing serum TC levels (SMD = -0.584, 95% CI: -0.980 to -0.188, P = 0.004); however, the efficacy is yet to be confirmed. Serum HDL-C levels were not obviously improved. Turmeric and curcumin appeared safe, and no serious adverse events were reported in any of the included studies.

 

Authors concluded turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels.

 

Qin S, Huang L, Gong J, Shen S, Huang J, Ren H, Hu H. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J. 2017 Oct 11;16(1):68

 

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Thursday, December 21, 2017
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This prospective, randomized controlled trial was conducted to evaluate the incidence of gestational diabetes mellitus (GDM) with two different dietary models. 874 women completed the study and were supplemented with extra virgin olive oil (EVOO) and pistachios; or Control Group (CG, n = 500) in standard diet with limited fat intake.

177/874 women were diagnosed with GDM, 103/440 (23.4%) in CG and 74/434(17.1%) in IG, p = 0.012.

The crude relative risk (RR) for GDM was 0.73 (95% CI: 0.56-0.95; p = 0.020) IG vs CG and persisted after adjusted multivariable analysis, 0.75(95% CI: 0.57-0.98; p = 0.039).

IG had also significantly reduced rates of insulin-treated GDM, prematurity, Gestational weight gain (GWG) at 24-28 and 36-38 GW, emergency caesarean section (CS), perineal trauma, and small and large for gestational age (SGA and LGA)newborns.

 

 Mediterranean diet and incidence of gestational diabetes mellitus.

 

Authors concluded an early nutritional intervention with a supplemented MedDiet reduces the incidence of GDM and improves several maternal and neonatal outcomes.

 

Assaf-Balut C, García de la Torre N, Durán A, Fuentes M, Bordiú E, Del Valle L, Familiar C, Ortolá A, Jiménez I, Herraiz MA, Izquierdo N, Perez N, Torrejon MJ, Ortega MI, Illana FJ, Runkle I, de Miguel MP, Montañez C, Barabash A, Cuesta M, Rubio MA, Calle-Pascual AL. A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): A randomized controlled trial: The St. Carlos GDM prevention study. PLoS One. 2017 Oct 19;12(10):e0185873.

 

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Tuesday, December 19, 2017
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These randomized, crossover, double-blind, placebo-controlled studies aimed to determine whether pomegranate polyphenols could lower the glycemic response of a high-glycemic index food when consumed together.

 

Pomegranate polyphenols beverage

 

The acute effect of a pomegranate juice and a polyphenol-rich extract from pomegranate (supplement) were compared on the bread-derived postprandial blood glucose concentration in 2 studies, each on 16 healthy volunteers. An additional study on 16 volunteers consuming constituent fruit acids in a pH-balanced solution (the same as pomegranate) and bread was conducted to determine contributions to postprandial responses caused by acidic beverages.

As primary outcome, the incremental AUC for bread-derived blood glucose (-33.1% ± 18.1%, p = 0.000005) and peak blood glucose (25.4% ± 19.3%, p = 0.0004) were attenuated by pomegranate juice, compared with a control solution containing the equivalent amount of sugars. In contrast, the pomegranate supplement, or a solution containing the malic and citric acid components of the juice, was ineffective. The pomegranate polyphenol punicalagin was a very effective inhibitor of human α-amylase in vitro, comparable to the drug acarbose.

These data indicate that pomegranate polyphenols, when present in a beverage but not in a supplement, can reduce the postprandial glycemic response of bread, whereas microbial metabolites from pomegranate polyphenols exhibit the potential to further modulate sugar metabolism much later in the postprandial period.

 

Kerimi A, Nyambe-Silavwe H, Gauer JS, Tomás-Barberán FA, Williamson G. Pomegranate juice, but not an extract, confers a lower glycemic response on a high-glycemic index food: randomized, crossover, controlled trials in healthy subjects. Am J Clin Nutr. 2017 Oct 11.

 

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Thursday, December 14, 2017
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Valerian is known for its effects on anxiety and sleep disorders. In order to clarify the mechanisms of action of valerian, this randomized, double-blind, placebo-controlled and crossover study examined the acute effect of valerian (900 mg of extract, 0.8% valerenic acid) on cortical excitability assessed with transcranial magnetic stimulation.

 

valerian

 

15 healthy subjects have been enrolled. Measures have been taken 1 and 6h after the oral administration.

The authors reported a significant reduction in intracortical facilitation that return to baseline value 6h after the intake of valerian. No other effect of valerian have been measured.

 

The authors concluded that valerian modulates intracortical facilitatory circuits. However, these results have to be confirmed in patients with anxiety or sleep disorders.

  

 

Mineo L, Concerto C, Patel D, Mayorga T, Paula M, Chusid E, Aguglia E, Battaglia F. Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans. Neuropsychobiology. 2017 Oct 17;75(1):46-51.

 

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