Nutraveris
Tuesday, January 22, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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The aim of this parallel-group, triple-blind, placebo-controlled randomized clinical trial was to investigate the effect of alpha lipoic acid (ALA) on uterine wound healing after primary cesarean section (CS).

To do so, 102 women undergoing pre-labor primary CS were randomized to receive either oral ALA (Thiotacid® film-coated tablet 600 mg, twice daily) or a placebo twice daily for 6 weeks after CS.

Results showed that twenty (39.2%) women in the treatment group and ten (19.6%) controls had no niche (p = 0.03). The absolute and relative risk reduction of forming a niche was 19.61% and 24.39%, respectively. The number of women needed to treat was five to avoid one niche formation. ALA use was associated with gastrointestinal upset in only three participants; however, none of the women withdrew during the study.

 

The cesarean section scar-related measurements

The cesarean section scar-related measurements in the two groups.

 

Authors concluded that women undergoing primary CS, the administration of ALA for 6 weeks postpartum improved uterine healing and decreased the incidence of scar niche.

 

Sammour H, Elkholy A, Rasheedy R, Fadel E. The effect of alpha lipoic acid on uterine wound healing after primary cesarean section: a triple-blind placebo-controlled parallel-group randomized clinical trial. Arch Gynecol Obstet. 2018 Dec 18.

 

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Thursday, January 17, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This in vivo study evaluated on atopic dermatitis-like hairless rat model the effects of 0.3 mL of lactic acid bacteria metabolites supplementation during 28 days on water content in the stratum corneum, transepidermal water loss (TEWL), ceramide AP content in the stratum corneum, and epidermis thickness.

Transepidermal water loss (TEWL) and water content of stratum corneum

Transepidermal water loss (TEWL) and water content of stratum corneum in normal rats (Normal), atopic dermatitis-like hairless rat model (Control) and atopic dermatitis-like hairless rat model treated with lactic acid bacteria metabolites (LFP). *** p < 0.001 (Tukey’s post-hoc test).

After supplementation, all measured parameters were improved in atopic dermatitis-like hairless rat model. Author also evaluated components responsible for these effects and showed that water-soluble components and residue obtained after filtration had no effects, whereas the lipid fraction showed similar effects to the raw liquid.

 

In conclusion, lactic acid bacteria metabolites, localized in the lipid fraction, improve skin injury in an atopic dermatitis-like murine model.

 

Tokudome Y. Influence of Oral Administration of Lactic Acid Bacteria Metabolites on Skin Barrier Function and Water Content in a Murine Model of Atopic Dermatitis. Nutrients 2018, 10(12), 1858.

 

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Tuesday, January 15, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

The purpose of this randomized and placebo-controlled study was to examine the effects of a lemon balm supplementation in subjects with type 2 diabetes. 62 patients have been recruited and have received for 12 weeks either a placebo or a lemon balm capsule (1400 mg/day).

Lemon balm

Results showed that lemon balm had significant effects on fasting blood glucose (p = 0.007), HbA1c (p = 0.002), triglycerides (p = 0.04), HDL-cholesterol (p = 0.05), hs-CRP (p = 0.001) and systolic blood pressure (p = 0.04). No change in total and LDL-cholesterol, insulin and insulin sensitivity have been noted.

 

These results suggest that lemon balm may improve the metabolic status of type 2 diabetic patients, reducing probably the risk of cardiovascular diseases.

 

 

Asadi A, Shidfar F, Safari M, Hosseini AF, Fallah Huseini H, Heidari I, Rajab A. Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial. Phytother Res. 2018 Dec 10.

 

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Thursday, January 10, 2019
Category : NEWS, INGREDIENTS, INNOVATION, CLINICAL EVIDENCE | Author : experts | Comment : No Comments
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This randomized, double-blinded and placebo-controlled study has been conducted in 48 women with gestational diabetes. They were randomized to receive a capsules contained a placebo or a probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum and Lactobacillus fermentum (2 × 109 CFU/g each) for 6 weeks.

 

gestational diabetes

This supplementation has reduced fasting blood glucose (p = 0.02), serum insulin levels (p = 0.001), and has increased insulin sensitivity (p = 0.001). Moreover, the probiotic supplementation has reduced plasma triglycerides (p = 0.02), VLDL-cholesterol (p = 0.02), and total/HDL-cholesterol ratio (p = 0.006), whereas HDL-cholesterol has been increased (p = 0.03). These effects may be explained at least in part by changes in gene expression, with for instance an increase expression of PPAR-γ (p = 0.01), transforming growth factor beta (p = 0.002) and vascular endothelial growth factor (p = 0.006).

 

Therefore, this clinical study shows that a probiotic supplementation may be an alternative approach for the management of gestational diabetes.

 

 

Babadi M, Khorshidi A, Aghadavood E, Samimi M, Kavossian E, Bahmani F, Mafi A, Shafabakhsh R, Satari M, Asemi Z. The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2018 Dec 8.

 

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Tuesday, January 8, 2019
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NOL, Nutraveris Online, the most efficient data solution to create, keep up-to-date and launch your products in the 28 EU member states, used for 10years by more than 500 industry leaders informs you:

 

This placebo-controlled in vivo study evaluated in gestational rats the effects of safflower oil supplementation of mothers during brain development period (from 14th day of gestation throughout lactation) on the brain electrophysiology and cortical oxidative status in the offspring.

Biomarkers of cortical oxidative status in rats

Biomarkers of cortical oxidative status (in right or left brain part) in rats that were previously raised by mothers which received safflower (SG) or control oil (CG) in their diet during pregnancy and throughout lactation. MDA: Malondialdehyde; SOD: Superoxide dismutase; CAT: Catalase; GST: Glutathione-s-transferase; GSH: Glutathione

 

Offspring from supplemented mothers presented reduction of the cortical spreading depression showing a greater brain excitability compared to placebo group. They also presented a reduction by 39.4% of lipid peroxidation (p < 0.05) compared to placebo. Supplementation reduced superoxide dismutase activity by 40.4% and catalase activity by 64.1% compared to placebo (p < 0.05) but increased activity of glutathione-S-transferase and glutathione level (p < 0.05) compared to placebo.

In conclusion this study demonstrated a long-lasting effect on brain excitability and oxidative stress biomarkers in the offspring born from dams that received safflower oil from the 14th day of gestation until the end of lactation.

 

Mendes-da-Silva RF, Ferreira DJS, Lopes-de-Morais AAC, Cavalcanti de Macêdo PF, Lagranha CJ, Batista-de-Oliveira-Hornsby M. Safflower (Carthamus tinctorius L.) oil during pregnancy and lactation influences brain excitability and cortex oxidative status in the rat offspring. Nutritional Neuroscience. 2017 Aug 04:1-8.

 

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With NOL let’s : 

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