Thursday, June 10, 2010
Category : NUTRILEGAL, food safety | Author : experts | Comment : No Comments
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EFSA has published opinions on conjugated linoleic acid (CLA) as a novel ingredient, provided by Clarinol®, manufactured by Lipid Nutrition and Tonalin®, manufactured by Cognis for which the characteristics are presented in the following table.

Characteristics Clarinol® Tonalin®
CLA rate (%) 80 80
Ratio of mixture of cis-9,trans-11 and trans-10,cis-12 isomers 1:1 1:1
Recommended daily dose by the applicant 3,75 g of Clarinol®, corresponding to 3 g of CLA 4,5 g of Tonalin®, corresponding to 3,5 g of CLA
Food containing the ingredient Beverages, cereal products, food supplements, dairy products, dry weight beverages for slimming purposes Milk-, yogurt- and fruit-products

EFSA concluded that for these two ingredients, their use in people of normal weight, overweight or obese, but not type 2 diabetes, was safe for a maximum period of six months. Indeed, consumption of CLA did not appear to have adverse effects on insulin sensitivity, control of blood glucose or liver function and the observed effects on blood lipid parameters have no apparent impact on cardiovascular risk in these individuals for the duration of exposure. However, there is insufficient evidence to conclude that it is safe over a period of higher exposure and in subjects with type 2 diabetes.

The Clarinol® Tonalin® and can therefore be used as a source of CLA in accordance with their respective terms of use.


Thursday, May 20, 2010
Category : CONVICTIONS, INGREDIENTS | Author : experts | Comment : No Comments
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While some studies have revealed an interesting effect of conjugated linoleic acid for the slimming market segment, showing a reduction of body fat and preserving lean body mass, other studies show a least interesting face of CLA. Thus, this new study of Kennedy et al., supports previous results showing that CLA induces inflammation and insulin resistance in adipocytes.

Reference: Kennedy A, Martinez K, Chung S, Lapoint K, Hopkins R, Schmidt SF, Anderson K, Mandrup S, McIntosh M. Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid are dependent on intracellular calcium levels in primary cultures of human adipocytes. J Lipid Res. 2010 Feb 14